Glen A I, Dodd M, Hulme E B, Kreitman N
Neuropsychobiology. 1979;5(3):167-73. doi: 10.1159/000117679.
A register of patients receiving lithium in the Edinburgh and Lothian area of Scotland has been kept by the Medical Research Council Brain Metabolism Unit since 1967. Using this register, information was obtained on 784 patients receiving lithium for a period of up to 115 months (97.4% of the population available for study). 33 patients died during the period of study due predominantly to cardiovascular causes or to suicide. There was nothing to suggest that long-term exposure caused more deaths than short-term exposure and the pattern of mortality resembled that found in other studies of manic-depressive illness, i.e. the majority of deaths occurred in the early stages of follow-up.
自1967年以来,苏格兰爱丁堡和洛锡安地区接受锂治疗的患者登记册一直由医学研究委员会脑代谢研究室保存。利用该登记册,获取了784名接受锂治疗长达115个月患者的信息(占可研究人群的97.4%)。在研究期间,33名患者死亡,主要死因是心血管疾病或自杀。没有迹象表明长期暴露比短期暴露导致更多死亡,而且死亡模式与其他躁郁症研究中发现的模式相似,即大多数死亡发生在随访的早期阶段。