Uldall P R, Awad A G, McCormick W O, Carter L B, Gonsick T, Grass C L, Kugelmass M I
Can Med Assoc J. 1981 Jun 1;124(11):1471-4.
Renal function was assessed in 42 stable outpatients who had been taking lithium for an average of 4 1/2 years. Impaired ability to concentrate the urine was found in 61% of the 41 patients who provided a urine sample for an osmolality measurement, and a moderate reduction in creatinine clearance was present in 12% of the entire group; 1 patient showed both defects. Urine microscopy revealed an excess of cells in 40%. It is suggested that lithium therapy produces a self-limiting lesion of the distal nephron that does not usually progress to chronic renal failure. The lesion is not dangerous, except that it may predispose to acute neurotoxic effects in the event of intercurrent illness or dehydration.
对42名稳定的门诊患者的肾功能进行了评估，这些患者平均服用锂盐4年半。在提供尿液样本进行渗透压测量的41名患者中，61%的患者尿液浓缩能力受损，在整个研究组中，12%的患者肌酐清除率中度降低；1名患者同时出现这两种缺陷。尿液显微镜检查显示40%的患者细胞过多。有人认为，锂盐治疗会导致远端肾单位出现自限性病变，通常不会发展为慢性肾衰竭。这种病变并不危险，只是在并发疾病或脱水时，可能会增加急性神经毒性作用的易感性。
