Kano K, Suda T
Eur J Pediatr. 1982 Mar;138(2):162-5. doi: 10.1007/BF00441145.
The effect of prednisone therapy on serum levels of 25-hydroxyvitamin D [25(OH)D] and 24,25-dihydroxyvitamin D [24,25(OH)2D] was investigated in 16 children with nephrotic syndrome. These serum levels were significantly lower in patients before prednisone therapy than in age- and season-matched normal subjects. Patients receiving daily prednisone therapy had lower serum levels than those receiving alternate-day prednisone therapy at the time when the total amounts of the steroid administered attained 1,500 or 2,000 mg/m2 of body surface area. Daily doses of 40 mg/m2 of prednisone for 3 days caused a significant decrease in serum 25(OH)D levels. Withdrawal of the steroid for 4 consecutive days was followed by a significant recovery of the serum levels. These results suggest that alternate-day prednisone therapy rather than daily treatment should be used in clinical practice to help maintain normal vitamin D metabolism.
对16名肾病综合征患儿研究了泼尼松治疗对血清25-羟基维生素D[25(OH)D]和24,25-二羟基维生素D[24,25(OH)2D]水平的影响。泼尼松治疗前患者的这些血清水平显著低于年龄和季节匹配的正常受试者。当给予的类固醇总量达到1500或2000mg/m²体表面积时，接受每日泼尼松治疗的患者血清水平低于接受隔日泼尼松治疗的患者。每日剂量40mg/m²的泼尼松连续服用3天导致血清25(OH)D水平显著下降。连续4天停用类固醇后，血清水平显著恢复。这些结果表明，临床实践中应采用隔日泼尼松治疗而非每日治疗，以帮助维持正常的维生素D代谢。
