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人宫颈癌脱落细胞中疱疹病毒抗原的免疫荧光检测

Immunofluorescent detection of herpesvirus antigens in exfoliated cells from human cervical carcinoma.

作者信息

Royston I, Aurelian L

出版信息

Proc Natl Acad Sci U S A. 1970 Sep;67(1):204-12. doi: 10.1073/pnas.67.1.204.

DOI:10.1073/pnas.67.1.204
PMID:4318779
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC283189/
Abstract

Exfoliated cells from patients with squamous carcinoma of the cervix contain antigens related to herpesvirus subtype 2, as revealed by direct or indirect immunofluorescent techniques. Normal squamous cells from the same subjects and from controls without the disease, and cells from a small number of tumors at sites other than the cervix, did not react with anti-herpesvirus subtype 2 serum. Antisera to adenovirus 18 or mycoplasma orale did not react with the exfoliated cells.

摘要

直接或间接免疫荧光技术显示，宫颈癌鳞状细胞癌患者的脱落细胞含有与2型疱疹病毒相关的抗原。来自同一受试者和无该疾病对照的正常鳞状细胞，以及来自宫颈以外少数肿瘤部位的细胞，均不与抗2型疱疹病毒血清发生反应。抗18型腺病毒血清或抗口腔支原体血清均不与脱落细胞发生反应。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c542/283189/26d5535c4f5e/pnas00099-0217-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c542/283189/d1303d52c6e2/pnas00099-0215-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c542/283189/26d5535c4f5e/pnas00099-0217-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c542/283189/d1303d52c6e2/pnas00099-0215-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c542/283189/26d5535c4f5e/pnas00099-0217-a.jpg

相似文献

1
Immunofluorescent detection of herpesvirus antigens in exfoliated cells from human cervical carcinoma.人宫颈癌脱落细胞中疱疹病毒抗原的免疫荧光检测
Proc Natl Acad Sci U S A. 1970 Sep;67(1):204-12. doi: 10.1073/pnas.67.1.204.
2
Occurrence of herpes- and adenovirus antibodies in patients with carcinoma of the cervix uteri. Measurement of antibodies to herpesvirus hominis (types 1 and 2), cytomegalovirus, EB-virus, and adenovirus.子宫颈癌患者中疱疹病毒和腺病毒抗体的出现情况。人疱疹病毒（1型和2型）、巨细胞病毒、EB病毒及腺病毒抗体的检测。
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Herpesvirus antigens as markers for cervical cancer.
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[Detection of herpes simplex virus antigen in human cervical carcinoma tissue].[人宫颈癌组织中单纯疱疹病毒抗原的检测]
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Herpes simplex virus-specific antigens in exfoliated cervical cells from women with and without cervical anaplasia.患有和未患有宫颈发育异常的女性脱落宫颈细胞中的单纯疱疹病毒特异性抗原
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Possible role of Herpesvirus hominis, type 2, in human cervical cancer.人疱疹病毒2型在人类宫颈癌中的可能作用。
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Herpesvirus type 2-induced tumour-specific antigen (AG-4) and specific antibody in patients with cervical cancer and controls.2型疱疹病毒诱导的宫颈癌患者及对照者肿瘤特异性抗原（AG-4）和特异性抗体
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引用本文的文献

1
Antigens of carcinoma of the cervix uteri. A study by means of immunofluorescence.子宫颈癌抗原。免疫荧光法研究
Clin Exp Immunol. 1974 Jan;16(1):53-62.
2
[Histopathologic and cytophotometric study of dysplastic and precancerous condyloma acuminata(author's transl)].发育异常及癌前尖锐湿疣的组织病理学与细胞光度学研究（作者译）
Arch Gynakol. 1974 Mar 12;216(2):119-32. doi: 10.1007/BF00668386.
3
Neoplasms, differentiations and mutations.肿瘤、分化与突变。

本文引用的文献

1
Localization of antigen in tissue cells; improvements in a method for the detection of antigen by means of fluorescent antibody.组织细胞中抗原的定位；通过荧光抗体检测抗原的方法的改进。
J Exp Med. 1950 Jan 1;91(1):1-13. doi: 10.1084/jem.91.1.1.
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The irrigation smear. A cytologic method for mass population screening by mail.冲洗涂片法。一种通过邮件进行大规模人群筛查的细胞学方法。
Am J Obstet Gynecol. 1962 Oct 15;84:1017-23.
3
Fluorescent antibody studies with agents of varicella and herpes zoster propagated in vitro.对水痘和带状疱疹病原体在体外繁殖进行的荧光抗体研究。
Am J Pathol. 1974 Oct;77(1):103-118.
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Are viruses important in carcinogenesis?病毒在致癌过程中重要吗？
Am J Pathol. 1974 Oct;77(1):85-102.
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The latent herpes simplex virus.潜伏性单纯疱疹病毒
Bacteriol Rev. 1974 Dec;38(4):337-55. doi: 10.1128/br.38.4.337-355.1974.
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Biologic and immunologic comparison of two HSV-2 variants: one an isolate from cervical tumor cells.两种单纯疱疹病毒2型变体的生物学和免疫学比较：一种是从宫颈肿瘤细胞中分离出的毒株。
Arch Gesamte Virusforsch. 1974;45(1-2):27-38. doi: 10.1007/BF01240539.
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Virus type-specific thymidine kinase in cells biochemically transformed by herpes simplex virus types 1 and 2.单纯疱疹病毒1型和2型生化转化细胞中的病毒型特异性胸苷激酶
J Virol. 1974 Jan;13(1):140-5. doi: 10.1128/JVI.13.1.140-145.1974.
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A DNA fragment of Herpes simplex 2 and its transcription in human cervical cancer tissue.单纯疱疹病毒2型的DNA片段及其在人宫颈癌组织中的转录。
Proc Natl Acad Sci U S A. 1972 Dec;69(12):3784-9. doi: 10.1073/pnas.69.12.3784.
9
Antibodies to surface antigens of herpesvirus type 1- and type 2-infected cells among women with cervical cancer and control women.宫颈癌女性和对照女性中针对1型和2型疱疹病毒感染细胞表面抗原的抗体。
Infect Immun. 1972 Mar;5(3):305-10. doi: 10.1128/iai.5.3.305-310.1972.
10
Herpesvirus hominis specific antigen in cells of human malignant glioma.人类恶性神经胶质瘤细胞中的人疱疹病毒特异性抗原。
Naturwissenschaften. 1972 Sep;59(9):424. doi: 10.1007/BF00623143.
Proc Soc Exp Biol Med. 1954 Aug-Sep;86(4):789-94. doi: 10.3181/00379727-86-21235.
4
A search for viruses in smegma, premalignant and early malignant cervical tissues. The isolation of Herpesviruses with distinct antigenic properties.对包皮垢、癌前和早期恶性宫颈组织中的病毒进行搜索。分离出具有独特抗原特性的疱疹病毒。
Am J Epidemiol. 1968 May;87(3):647-55. doi: 10.1093/oxfordjournals.aje.a120855.
5
The association of genital herpesvirus with cervical atypia and carcinoma in situ.生殖器疱疹病毒与宫颈异型增生及原位癌的关联。
Am J Epidemiol. 1970 Jun;91(6):531-8. doi: 10.1093/oxfordjournals.aje.a121164.
6
Genital infection with type 2 Herpes virus hominis. A commonly occurring venereal disease.人2型疱疹病毒引起的生殖器感染。一种常见的性病。
Br J Vener Dis. 1969 Dec;45(4):294-8. doi: 10.1136/sti.45.4.294.
7
Typing of Herpesvirus hominis strains by a direct immunofluorescent technique.应用直接免疫荧光技术对人疱疹病毒毒株进行分型
Proc Soc Exp Biol Med. 1969 Oct;132(1):386-90. doi: 10.3181/00379727-132-34221.
8
Biological markers for differentiation of herpes-virus strains of oral and genital origin.用于区分口腔和生殖器来源疱疹病毒株的生物标志物。
J Gen Virol. 1969 Mar;4(2):259-67. doi: 10.1099/0022-1317-4-2-259.
9
Antigenic and biologic differences in herpesvirus hominis.人疱疹病毒的抗原性和生物学差异。
Prog Med Virol. 1968;10:110-59.
10
Genital infection with Herpesvirus hominis types 1 and 2 in children.儿童1型和2型人疱疹病毒的生殖器感染。
Pediatrics. 1968 Oct;42(4):659-66.