Brier A M, Snyderman R, Mergenhagen S E, Notkins A L
Science. 1970 Dec 4;170(3962):1104-6. doi: 10.1126/science.170.3962.1104.
Infection of primary rabbit kidney cells with herpes simplex virus leads to the release of a cell factor or factors that upon incubation with serum results in the cleavage of the fifth component, C5, of complement. The product of this cleavage, C5a, is chemotactic for polymorphonuclear leukocytes and could be responsible for the accumulation of these cells at the site of herpetic lesions.
单纯疱疹病毒感染原代兔肾细胞会导致一种或多种细胞因子的释放，这些因子与血清一起孵育时会导致补体第五成分C5的裂解。这种裂解的产物C5a对多形核白细胞具有趋化作用，可能是这些细胞在疱疹病变部位积聚的原因。
