单纯疱疹病毒刺激人白细胞产生趋化因子和淋巴毒素。
Production of chemotactic factor and lymphotoxin by human leukocytes stimulated with Herpes simplex virus.
作者信息
Rosenberg G L, Snyderman R, Notkins A L
出版信息
Infect Immun. 1974 Jul;10(1):111-5. doi: 10.1128/iai.10.1.111-115.1974.
Peripheral blood leukocytes (PBL) of 41 subjects were tested for their ability to be stimulated by herpes simplex virus antigens as measured by [(3)H]thymidine incorporation and lymphokine production (i.e., lymphocyte-derived chemotactic factor and lymphotoxin). The PBL of seronegative subjects failed to respond to viral antigens as measured by stimulation or lymphokine production. In contrast, PBL from seropositive subjects without clinical lesions of herpes labialis were stimulated by herpes simplex virus antigens and produced lymphokines. PBL from seropositive patients with clinical lesions of herpes labialis also produced lymphokines, but [(3)H]thymidine incorporation was slightly depressed. These findings suggest that lymphocytes from patients with a recent herpes simplex virus infection may respond less vigorously to in vitro stimulation by herpes antigens, but our study fails to show any basic defect in the responsiveness of the lymphocytes to account for recurrent herpetic episodes.
通过[³H]胸腺嘧啶核苷掺入法和淋巴因子产生（即淋巴细胞衍生趋化因子和淋巴毒素），检测了41名受试者外周血白细胞（PBL）受单纯疱疹病毒抗原刺激的能力。血清阴性受试者的PBL在刺激或淋巴因子产生方面对病毒抗原无反应。相比之下，无唇疱疹临床病变的血清阳性受试者的PBL受到单纯疱疹病毒抗原刺激并产生淋巴因子。有唇疱疹临床病变的血清阳性患者的PBL也产生淋巴因子，但[³H]胸腺嘧啶核苷掺入略有降低。这些发现表明，近期感染单纯疱疹病毒患者的淋巴细胞对疱疹抗原的体外刺激反应可能较弱，但我们的研究未能显示淋巴细胞反应性存在任何基本缺陷以解释复发性疱疹发作。
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