Taylor M W, Cordell B, Souhrada M, Prather S
Proc Natl Acad Sci U S A. 1971 Apr;68(4):836-40. doi: 10.1073/pnas.68.4.836.
Treatment of ascites and solid tumors in mice (Sarcoma-1 and Ehrlich ascites carcinoma) with bovine enterovirus-1 resulted in regression of the tumors without any pathological effect on the animals. Death of mice with lymphatic-leukemia L4946 was delayed after such treatment. The oncolytic specificity of the virus does not appear to involve the production of interferon, but requires specific adsorption of virus to the tumor cells. The specificity of killing extends to cells in culture, since viral-transformed cells and oncogenic cells are susceptible to the virus, in contrast to cells of untransformed lines and cells of primary cultures, which are resistant. The possibility of utilizing the specificity of nonvirulent viruses in therapeutic treatment of human cancers is considered.
用牛肠道病毒-1治疗小鼠腹水和实体瘤（肉瘤-1和艾氏腹水癌）导致肿瘤消退，且对动物无任何病理影响。经此治疗后，患淋巴白血病L4946的小鼠死亡时间延迟。该病毒的溶瘤特异性似乎不涉及干扰素的产生，而是需要病毒特异性吸附到肿瘤细胞上。杀伤特异性延伸至培养细胞，因为病毒转化细胞和致癌细胞对该病毒敏感，而未转化细胞系的细胞和原代培养细胞具有抗性。文中考虑了利用无毒病毒的特异性进行人类癌症治疗的可能性。
