McLAREN L C, HOLLAND J J, SYVERTON J T
J Exp Med. 1959 May 1;109(5):475-85. doi: 10.1084/jem.109.5.475.
Primary or established strain cultures of a variety of primate cells that were susceptible to cytopathic infection strongly adsorbed poliovirus. Insusceptible non-primate cells in primary or established-strain culture did not so adsorb virus (or propagate it), with exception of the ERK-1 embryo rabbit kidney strain. All tested cells, regardless of type or susceptibility, adsorbed about 1 per cent of input virus, which became cell-associated (CAV) without loss of infectivity. In combination with susceptible or insusceptible cells, CAV was only about 90 per cent neutralized by homotypic antiserum. CAV eluted continuously from non-susceptible cells with continued incubation; eluted virus gave rise to infection and new CAV to the same degree in susceptible cells as did original virus.
多种易受细胞病变感染的灵长类细胞的原代或传代培养物能强烈吸附脊髓灰质炎病毒。原代或传代培养的不易感非灵长类细胞不会如此吸附病毒（或使其增殖），但ERK - 1胚胎兔肾细胞系除外。所有测试细胞，无论类型或易感性如何，均吸附约1%的输入病毒，这些病毒与细胞结合（CAV）且不丧失感染性。与易感或不易感细胞结合时，CAV仅被同型抗血清中和约90%。持续孵育时，CAV从不易感细胞中持续洗脱；洗脱的病毒在易感细胞中引发感染并产生与原始病毒相同程度的新CAV。
