Giron D J, Allen P T, Pindak F F, Schmidt J P
Appl Microbiol. 1971 Mar;21(3):387-93. doi: 10.1128/am.21.3.387-393.1971.
Interferon induction by MM virus in mice and in L cells was studied. In mice the virus readily induced interferon. The time of appearance was dose-dependent. A large virus dose induced interferon by 4 hr, whereas a small dose resulted in interferon production which paralleled virus replication 24 hr after infection. In L cells the interferon-inducing capacity of the virus was rapidly destroyed by ultraviolet light irradiation. Heating (56 C) of the virus, on the other hand, greatly increased its ability to induce interferon. Interferon production could also be increased by prior treatment of the cells with homologous interferon (priming). The increase in interferon production after priming was dependent on the concentration of interferon used for priming, the length of interferon treatment, and the multiplicity of infection. It is suggested that MM virus might be useful for the further study of the mechanisms involved in the production and action of interferon.
对小鼠和L细胞中MM病毒诱导干扰素的情况进行了研究。在小鼠中，该病毒很容易诱导产生干扰素。出现的时间呈剂量依赖性。大剂量病毒在4小时内诱导产生干扰素，而小剂量则导致在感染后24小时产生与病毒复制平行的干扰素。在L细胞中，病毒的干扰素诱导能力会因紫外线照射而迅速被破坏。另一方面，病毒加热（56℃）会大大增强其诱导干扰素的能力。用同源干扰素预处理细胞（致敏）也可增加干扰素的产生。致敏后干扰素产生的增加取决于用于致敏的干扰素浓度、干扰素处理的时长以及感染复数。有人提出，MM病毒可能有助于进一步研究干扰素产生和作用所涉及的机制。
