脑心肌炎病毒在L细胞中诱导的细胞病变效应：干扰素的保护作用。
Mengovirus-induced cytopathic effect in L-cells: protective effect of interferon.
作者信息
Haase A T, Levy H, Baron S, Kasel J A
出版信息
J Virol. 1969 Oct;4(4):490-5. doi: 10.1128/JVI.4.4.490-495.1969.
Abstract
The effect of interferon on mengovirus-induced cytopathic effect (CPE) in L cells, the cut-off of host-cell protein synthesis, and production of mature virus were found to be dependent on the concentration of interferon. CPE and inhibition of host protein synthesis were not affected until the concentration of interferon was increased 100-fold over that required to reduce viral yields by 90%.
摘要
研究发现，干扰素对L细胞中 mengovirus 诱导的细胞病变效应（CPE）、宿主细胞蛋白质合成的阻断以及成熟病毒的产生的影响取决于干扰素的浓度。在干扰素浓度比将病毒产量降低90%所需浓度提高100倍之前，CPE和宿主蛋白质合成的抑制均未受到影响。
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