Corradino R A, Wasserman R H
Science. 1971 May 14;172(3984):731-3. doi: 10.1126/science.172.3984.731.
Induction of the synthesis of calcium-binding protein in chick embryonic intestine maintained in vitro was accomplished by simply adding vitamin D(3) to the culture medium. Accompanying the induction of this protein, there was enhanced radiocalcium uptake by the intestine. These observations represent the first demonstration of an in vitro physiological effect of vitamin D(3) on the calcium absorptive mechanism of the intestine.
通过简单地向培养基中添加维生素D(3)，就能在体外维持的鸡胚肠中诱导钙结合蛋白的合成。随着这种蛋白质的诱导，肠对放射性钙的摄取增强。这些观察结果首次证明了维生素D(3)对肠钙吸收机制的体外生理效应。
