Corradino R A
Science. 1973 Jan 26;179(4071):402-5. doi: 10.1126/science.179.4071.402.
Embryonic chick intestine maintained in organ culture responded to vitamin D(3) and its metabolites 25-hydroxycholecalciferol and 1,25-dihydroxycholecalciferol by synthesis of calcium-binding protein and enchanced calcium-45 uptake. The dihydroxy metabolite was by far the most potent inducer of the protein and also acted more rapidly than vitamin D(3) to stimulate isotope uptake. Despite its lower potency, vitamin D(3) itself was effective.
在器官培养中维持的鸡胚小肠，对维生素D₃及其代谢产物25-羟胆钙化醇和1,25-二羟胆钙化醇作出反应，合成钙结合蛋白并增强⁴⁵钙摄取。二羟基代谢产物是该蛋白迄今为止最有效的诱导剂，而且在刺激同位素摄取方面比维生素D₃作用更快。尽管效力较低，但维生素D₃本身也是有效的。
