Muller W A, Berger M, Suter P, Cüppers H J, Schmidt F H, Wyss T, Assal J P, Loizeau E
Schweiz Med Wochenschr. 1979 Apr 21;109(16):603-4.
Glucagon immunoreactivity (IRG) was measured in plasma of 8 duodenopancreatectomized patients with antiserum 30-K. Arginine infusions failed to raise plasma IRG, whereas in control subjects IRG rose 3-fold. Column chromatography revealed that the basal IRG measured in these plasmas was not due to glucagon (molecular weight 3485) but to other plasma factors, mainly of high molecular weight. This suggests that diabetes mellitus does not require the presence of glucagon to produce the clinical picture, as suggested by other authors. Plasma levels of the amino acids alanine, serine, ornithine, and arginine were significantly (p less than 0.05) elevated, the former two being gluconeogenic substrates and the latter two constituents of the urea cycle. This amino acid abnormality may be a consequence of glucagon deficiency.
用抗血清30-K测定了8例十二指肠胰腺切除患者血浆中的胰高血糖素免疫反应性（IRG）。精氨酸输注未能提高血浆IRG，而在对照受试者中，IRG升高了3倍。柱色谱分析表明，这些血浆中测得的基础IRG并非由于胰高血糖素（分子量3485），而是由于其他血浆因子，主要是高分子量的因子。这表明，正如其他作者所指出的，糖尿病并不需要胰高血糖素的存在来产生临床表现。血浆中氨基酸丙氨酸、丝氨酸、鸟氨酸和精氨酸的水平显著升高（p<0.05），前两者是糖异生底物，后两者是尿素循环的组成成分。这种氨基酸异常可能是胰高血糖素缺乏的结果。
