Ungerleider R S, Appelbaum F R, Trapani R J, Deisseroth A B
Transfusion. 1979 Jan-Feb;19(1):90-4. doi: 10.1046/j.1537-2995.1979.19179160275.x.
To clarify the relationship between recipient presensitization and response to granulocyte (PMN) transfusion, we tested 187 non-HL-A matched donor-recipient pairs for the presence of antileukocyte antibody using granulocytotoxicity (G), lymphocytotoxicity (L), microleukoagglutination (M), and capillary leukoagglutination (C) assays. PMN increments per 10(11) transfused PMNs per square meter of body surface area, ascertained one hour following termination of transfusion, and the occurrence of nonhemolytic transfusion reactions, were correlated with the assay results. Although circulating anti-donor-leukocyte antibody was detected in 52 per cent of recipients, there was no statistically significant relationship between the presence of these antibodies and either PMN recovery or incidence of transfusion reaction. We conclude that the prospective use of these assays is of little value in predicting the recipient's response to PMN transfusion.
为阐明受血者预致敏状态与对粒细胞（PMN）输血反应之间的关系，我们采用粒细胞毒性（G）、淋巴细胞毒性（L）、微量白细胞凝集（M）和毛细管白细胞凝集（C）试验，对187对非HL - A配型的供受者进行了抗白细胞抗体检测。在输血结束后1小时测定每平方米体表面积每输注10(11)个PMN后的PMN增加值，以及非溶血性输血反应的发生情况，并将其与检测结果进行关联分析。尽管在52%的受血者中检测到循环抗供者白细胞抗体，但这些抗体的存在与PMN恢复或输血反应发生率之间均无统计学上的显著关系。我们得出结论，这些检测方法在预测受血者对PMN输血的反应方面前瞻性应用价值不大。
