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1
Detection of foot-and-mouth disease virus antibodies. II. Use of fractionated bovine antisera for improving the specificity of a "passive" hemagglutination test.口蹄疫病毒抗体的检测。II. 使用分级分离的牛抗血清提高“被动”血凝试验的特异性。
Appl Microbiol. 1971 Jul;22(1):37-43. doi: 10.1128/am.22.1.37-43.1971.
2
Passive hemagglutination-inhibition test for typing foot-and-mouth disease virus.口蹄疫病毒分型的被动血凝抑制试验
Appl Microbiol. 1972 Jan;23(1):98-103. doi: 10.1128/am.23.1.98-103.1972.
3
Detection of foot-and-mouth disease virus antibodies. I. "Passive" hemagglutination test.口蹄疫病毒抗体的检测。I. “被动”血凝试验。
Appl Microbiol. 1970 Jul;20(1):35-9. doi: 10.1128/am.20.1.35-39.1970.
4
Foot-and-mouth disease virus in cattle and pigs: use of polyethylene glycol or dextran for purifying 19S gamma-M immunoglobulin from sera.
Arch Gesamte Virusforsch. 1971;33(1):134-44. doi: 10.1007/BF01254171.
5
Immunochemical studies of foot-and-mouh disease. IX. Differences in neutralizing activities of guinea pig and bovine 19S and 7S antibodies.口蹄疫的免疫化学研究。IX. 豚鼠和牛19S及7S抗体中和活性的差异。
J Immunol. 1971 Mar;106(3):656-60.
6
[The use of CrCl 3 for coupling of foot-and-mouth disease virus to erythrocytes, and the ability of these sensitized erythrocytes to react in passive hemagglutination (PHA) and passive immunohemolysis (PIH)].[使用三氯化铬将口蹄疫病毒与红细胞偶联，以及这些致敏红细胞在被动血凝反应（PHA）和被动免疫溶血反应（PIH）中的反应能力]
Arch Gesamte Virusforsch. 1972;38(2):205-15.
7
Escherichia coli agglutinins in cow serum, colostrum and the nursing calf.牛血清、初乳和哺乳犊牛中的大肠杆菌凝集素。
Can J Comp Med. 1970 Jul;34(3):213-7.
8
Immunochemical studies of foot-and-mouth disease. VII. Characterization of foot-and-mouth disease virus concentrated by polyethylene glycol precipitation.口蹄疫的免疫化学研究。VII. 用聚乙二醇沉淀法浓缩的口蹄疫病毒的特性
Arch Gesamte Virusforsch. 1970;30(4):343-52. doi: 10.1007/BF01258364.
9
Immunoglobulin E antibodies in guinea pigs: characterization of monomeric and polymeric components.豚鼠中的免疫球蛋白E抗体：单体和多聚体成分的特性
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10
Precipitation of 19S IgM rheumatoid factor-IgG circulating immune complexes in patients with juvenile arthritis by polyethylene glycol and separation by immobilized protein A.通过聚乙二醇沉淀青少年关节炎患者的19S IgM类风湿因子-IgG循环免疫复合物，并采用固定化蛋白A进行分离。
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引用本文的文献

1
Passive hemagglutination-inhibition test for typing foot-and-mouth disease virus.口蹄疫病毒分型的被动血凝抑制试验
Appl Microbiol. 1972 Jan;23(1):98-103. doi: 10.1128/am.23.1.98-103.1972.

本文引用的文献

1
The adsorption of proteins on erythrocytes treated with tannic acid and subsequent hemagglutination by antiprotein sera.蛋白质在经单宁酸处理的红细胞上的吸附以及随后抗蛋白质血清引起的血细胞凝集。
J Exp Med. 1951 Feb;93(2):107-20. doi: 10.1084/jem.93.2.107.
2
ANTIBODIES PRODUCED BY GUINEA PIGS INFECTED WITH FOOT-AND-MOUTH DISEASE VIRUS.感染口蹄疫病毒的豚鼠产生的抗体。
J Immunol. 1965 Jun;94:858-67.
3
PRODUCTION AND PURIFICATION OF MILLIGRAM AMOUNTS OF FOOT-AND-MOUTH DISEASE VIRUS FROM BABY HAMSTER KIDNEY CELL CULTURES.从幼仓鼠肾细胞培养物中生产和纯化毫克量的口蹄疫病毒
Appl Microbiol. 1964 Jul;12(4):368-73. doi: 10.1128/am.12.4.368-373.1964.
4
CHEMICAL PHYSICAL PROPERTIES OF VIRTUALLY PURE FOOT-AND-MOUTH DISEASE VIRUS.近乎纯口蹄疫病毒的化学物理特性
Am J Vet Res. 1964 Mar;25:333-42.
5
Micromethods for the study of proteins and antibodies. II. Specific applications of hemagglutination and hemagglutination-inhibition reactions with tannic acid and protein-treated red blood cells.蛋白质和抗体研究的微量方法。II. 鞣酸和蛋白质处理红细胞的血凝及血凝抑制反应的具体应用。
J Immunol. 1954 May;72(5):368-75.
6
Analysis of the diluents used for rubella virus hemagglutination and hemagglutination-inhibition tests.风疹病毒血凝及血凝抑制试验所用稀释剂的分析
Appl Microbiol. 1969 Aug;18(2):221-7. doi: 10.1128/am.18.2.221-227.1969.
7
Detection of foot-and-mouth disease virus antibodies. I. "Passive" hemagglutination test.口蹄疫病毒抗体的检测。I. “被动”血凝试验。
Appl Microbiol. 1970 Jul;20(1):35-9. doi: 10.1128/am.20.1.35-39.1970.
8
Late 19S rabbit antibody neutralization test for differentiating herpes simplex virus types 1 and 2.用于区分1型和2型单纯疱疹病毒的晚期19S兔抗体中和试验
J Immunol. 1970 Mar;104(3):593-8.
9
Immunochemical studies of foot-and-mouth disease. V. Antigenic variants of virus demonstrated by immunodiffusion analyses with 19S but not 7S antibodies.口蹄疫的免疫化学研究。V. 用19S而非7S抗体通过免疫扩散分析证明的病毒抗原变异体
J Exp Med. 1969 Feb 1;129(2):333-50. doi: 10.1084/jem.129.2.333.
10
Antibody heterogeneity and serological reactions.抗体异质性与血清学反应。
Bacteriol Rev. 1967 Jun;31(2):157-74. doi: 10.1128/br.31.2.157-174.1967.

口蹄疫病毒抗体的检测。II. 使用分级分离的牛抗血清提高“被动”血凝试验的特异性。

Detection of foot-and-mouth disease virus antibodies. II. Use of fractionated bovine antisera for improving the specificity of a "passive" hemagglutination test.

作者信息

Warrington R E, Kawakami Y

出版信息

Appl Microbiol. 1971 Jul;22(1):37-43. doi: 10.1128/am.22.1.37-43.1971.

DOI:10.1128/am.22.1.37-43.1971
PMID:4329433
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC377373/
Abstract

Because 7S immunoglobulin (Ig) G antibodies of low type specificity were present in mixtures with highly specific 19S IgM antibodies, many bovine antisera to foot-and-mouth disease virus (FMDV) type A(12), strain 119 cross-reacted with type O of FMDV and to some degree with type C in the passive hemagglutination (HA) test. After 19S IgM antibodies were separated by density gradient centrifugation or precipitated with 4% (w/v) polyethylene glycol, the antigen could be determined with "block" HA tests. Such tests used several antigen concentrations in the titration of each antiserum. Adding 4% (w/v) polyethylene glycol to the serum was especially convenient for rapid precipitation of 19S IgM antibodies for the test. Similar results were obtained with bovine 19S IgM antibodies to FMDV type O, subtype 1, strain Caseros and type C strain Rezende.

摘要

由于低型特异性的7S免疫球蛋白（Ig）G抗体与高特异性的19S IgM抗体混合存在，许多针对口蹄疫病毒（FMDV）A（12）型119株的牛抗血清在被动血凝试验（HA）中与FMDV O型发生交叉反应，并在一定程度上与C型发生交叉反应。通过密度梯度离心分离19S IgM抗体或用4%（w/v）聚乙二醇沉淀后，可用“阻断”HA试验测定抗原。此类试验在滴定每种抗血清时使用了几种抗原浓度。向血清中加入4%（w/v）聚乙二醇对于快速沉淀用于试验的19S IgM抗体特别方便。针对FMDV O型1亚型Caseros株和C型Rezende株的牛19S IgM抗体也获得了类似结果。