病毒诱导的细胞脱氧核糖核酸合成与猿猴病毒40转化之间的关系
Relationship between virus-induced cellular deoxyribonucleic acid synthesis and transformation by simian virus 40.
作者信息
Fox T O, Levine A J
出版信息
J Virol. 1971 Apr;7(4):473-7. doi: 10.1128/JVI.7.4.473-477.1971.
Abstract
The fraction of cells in a confluent 3T3 cell monolayer induced by simian virus 40 infection to replicate deoxyribonucleic acid and divide corresponds to those cells which eventually become transformed. Virus-induced cells were partially separated from noninduced cells by sedimentation through Ficoll gradients. Three- to eightfold higher transformation frequencies were obtained with those cells that began to synthesize cellular deoxyribonucleic acid and divide shortly after simian virus 40 infection as compared to noninduced cells.
摘要
在融合的3T3细胞单层中，被猿猴病毒40感染诱导进行脱氧核糖核酸复制和分裂的细胞比例，与最终发生转化的细胞相对应。通过菲可梯度沉降法将病毒诱导的细胞与未诱导的细胞部分分离。与未诱导的细胞相比，在猿猴病毒40感染后不久就开始合成细胞脱氧核糖核酸并进行分裂的那些细胞，其转化频率提高了三到八倍。
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