多瘤病毒非转化突变体中细胞膜改变功能的缺失。
Absence of a cell membrane alteration function in non-transforming mutants of polyoma virus.
作者信息
Benjamin T L, Burger M M
出版信息
Proc Natl Acad Sci U S A. 1970 Oct;67(2):929-34. doi: 10.1073/pnas.67.2.929.
Abstract
A surface receptor for an agglutinin, exposed in transformed but not in normal cells, arises in normal mouse cells during lytic infection by polyoma virus. The structural change in the surface membrane characteristic of transformed cells and of cells productively infected by wild type virus fails to occur in normal mouse cells infected by mutants of the virus that are unable to cause transformation. The exposure of the receptor site by wild type virus is reversibly blocked by inhibitors of DNA synthesis.
摘要
一种凝集素的表面受体在转化细胞而非正常细胞中暴露，它在多瘤病毒的裂解感染过程中出现在正常小鼠细胞中。转化细胞以及被野生型病毒有效感染的细胞所特有的表面膜结构变化，在被该病毒不能导致转化的突变体感染的正常小鼠细胞中不会发生。野生型病毒使受体位点暴露的过程可被DNA合成抑制剂可逆地阻断。
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