非缺陷型腺病毒2-猴病毒40杂交病毒的研究。IV. 野生型猴病毒40和非缺陷型杂交病毒Ad2+ND1诱导的猴病毒40核糖核酸种类的特性
Studies of nondefective adenovirus 2-simian virus 40 hybrid viruses. IV. Characterization of the simian virus 40 ribonucleic acid species induced by wild-type simian virus 40 and by the nondefective hybrid virus, Ad2 + ND 1 .
作者信息
Oxman M N, Levine A S, Crumpacker C S, Levin M J, Henry P H, Lewis A M
出版信息
J Virol. 1971 Aug;8(2):215-24. doi: 10.1128/JVI.8.2.215-224.1971.
Abstract
Ad2(+)ND(1), a nondefective adenovirus 2 (Ad2)-simian virus 40 (SV40) hybrid virus, has been previously shown to contain a small segment of the SV40 genome covalently linked to Ad2 deoxyribonucleic acid (DNA). The SV40 portion of this hybrid virus has been characterized by relating the SV40-specific ribonucleic acid (RNA) sequences transcribed from the Ad2(+)ND(1) DNA to those transcribed from the DNA of SV40 itself. RNA-DNA hybridization-competition studies indicate that the SV40 component of Ad2(+)ND(1) consists of some, but not all, of that part of the SV40 genome which is transcribed early, i.e., prior to viral DNA replication, in SV40 lytic infection.
摘要
Ad2(+)ND(1)是一种无缺陷的腺病毒2型（Ad2）-猴病毒40型（SV40）杂交病毒，先前已证明它含有一小段与Ad2脱氧核糖核酸（DNA）共价连接的SV40基因组。通过将从Ad2(+)ND(1) DNA转录的SV40特异性核糖核酸（RNA）序列与从SV40自身DNA转录的序列进行关联，对这种杂交病毒的SV40部分进行了表征。RNA-DNA杂交竞争研究表明，Ad2(+)ND(1)的SV40组分由SV40基因组中在SV40裂解感染中早期转录（即在病毒DNA复制之前）的部分组成，但并非全部。
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ADENOVIRUS-SV40 "HYBRIDS": PLAQUE PURIFICATION INTO LINES IN WHICH THE DETERMINANT FOR THE SV40 TUMOR ANTIGEN IS LOST OR RETAINED.腺病毒 - 猴病毒40“杂种病毒”：通过蚀斑纯化形成株系，其中猴病毒40肿瘤抗原的决定簇丢失或保留。
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INDUCTION BY ADENOVIRUS TYPE 7 OF TUMORS IN HAMSTERS HAVING THE ANTIGENIC CHARACTERISTICS OF SV40 VIRUS.7型腺病毒对具有SV40病毒抗原特性的仓鼠肿瘤的诱导作用
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