大肠杆菌中分解代谢物阻遏期间未翻译的乳糖特异性信使核糖核酸的积累。
Accumulation of untranslated lactose-specific messenger ribonucleic acid during catabolite repression in Escherichia coli.
作者信息
Aboud M, Burger M
出版信息
Biochem J. 1971 Apr;122(2):219-24. doi: 10.1042/bj1220219.
Abstract
When Escherichia coli K-12 Hfr.H was induced to synthesize beta-galactosidase in the presence of glucose, an untranslated lactose-specific mRNA (lac-mRNA), protected from decay, was found to accumulate progressively within the cells. The lac-mRNA accumulation was unaffected by the carbon source on which the cells had been grown before the induction. The amount of the lac-mRNA available for translation was affected by catabolite repression and 3':5'-cyclic AMP, but it remained unclear whether this was a direct effect on the formation of the lac-mRNA or a consequence of the effect on its translation.
摘要
当在葡萄糖存在的情况下诱导大肠杆菌K-12 Hfr.H合成β-半乳糖苷酶时，发现一种未翻译的乳糖特异性信使核糖核酸（lac- mRNA）在细胞内逐渐积累，且不受降解影响。lac- mRNA的积累不受诱导前细胞所生长碳源的影响。可用于翻译的lac- mRNA量受分解代谢物阻遏和3':5'-环磷酸腺苷的影响，但尚不清楚这是对lac- mRNA形成的直接作用，还是对其翻译产生影响的结果。
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