牛松果体的一种环磷酸腺苷依赖性蛋白激酶。
A cyclic AMP-dependent protein kinase of the bovine pineal gland.
作者信息
Fontana J A, Lovenberg W
出版信息
Proc Natl Acad Sci U S A. 1971 Nov;68(11):2787-90. doi: 10.1073/pnas.68.11.2787.
Abstract
A protein kinase that is dependent on cAMP was found to be present in significant amounts in rat and bovine pineal glands. This enzyme system was isolated from bovine pineal glands and shown to consist of two proteins, a kinase and a cAMP-binding protein. The kinase primarily phosphorylates histones and may function in the control of the diurnal variation of the enzymes in the melatonin biosynthetic pathway.
摘要
一种依赖于环磷酸腺苷（cAMP）的蛋白激酶被发现大量存在于大鼠和牛的松果体中。该酶系统从牛的松果体中分离出来，结果显示它由两种蛋白质组成，一种激酶和一种cAMP结合蛋白。这种激酶主要使组蛋白磷酸化，并可能在褪黑素生物合成途径中酶的昼夜变化控制中发挥作用。
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