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1
Elevated concentration of adenosine 3':5'-cyclic monophosphate in intestinal mucosa after treatment with cholera toxin.霍乱毒素处理后肠黏膜中3':5'-环磷酸腺苷浓度升高。
Proc Natl Acad Sci U S A. 1970 Oct;67(2):851-6. doi: 10.1073/pnas.67.2.851.
2
Effects of prostaglandins and cholera enterotoxin on intestinal mucosal cyclic AMP accumulation. Evidence against an essential role for prostaglandins in the action of toxin.前列腺素和霍乱肠毒素对肠黏膜环磷酸腺苷积累的影响。关于前列腺素在毒素作用中起关键作用的证据不足。
J Clin Invest. 1974 Mar;53(3):941-9. doi: 10.1172/JCI107635.
3
The effect of cholera toxin and heat labile and heat stable Escherichia coli enterotoxin on cyclic AMP concentrations in small intestinal mucosa of pig and rabbit.霍乱毒素、不耐热和耐热大肠杆菌肠毒素对猪和兔小肠黏膜中环磷酸腺苷浓度的影响。
Can J Comp Med. 1978 Jul;42(3):327-31.
4
Effect of cholera enterotoxin on ion transport across isolated ileal mucosa.霍乱肠毒素对离子跨孤立回肠黏膜转运的影响。
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Enterotoxin-induced fluid accumulation during experimental salmonellosis and cholera: involvement of prostaglandin synthesis by intestinal cells.实验性沙门氏菌病和霍乱期间肠毒素诱导的体液积聚：肠道细胞前列腺素合成的参与
Toxicon. 1985;23(1):157-72. doi: 10.1016/0041-0101(85)90118-7.
6
Lanthanum inhibition of Vibrio cholerae and Escherichia coli enterotoxin-induced enterosorption and its effects on intestinal mucosa cyclic adenosine 3',5'-monophosphate and cyclic guanosine 3',5'-monophosphate levels.镧对霍乱弧菌和大肠杆菌肠毒素诱导的肠吸收的抑制作用及其对肠黏膜环磷酸腺苷和环磷酸鸟苷水平的影响。
Infect Immun. 1975 May;11(5):1038-44. doi: 10.1128/iai.11.5.1038-1044.1975.
7
Comparison of the action of Escherichia coli enterotoxin on the thymocyte adenylate cyclase-cyclic adenosine monophosphate system to that of cholera toxin and prostaglandin E1.大肠杆菌肠毒素对胸腺细胞腺苷酸环化酶 - 环磷酸腺苷系统的作用与霍乱毒素和前列腺素E1作用的比较。
Infect Immun. 1974 Sep;10(3):503-9. doi: 10.1128/iai.10.3.503-509.1974.
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Vibrio cholerae metalloproteinase degrades intestinal mucin and facilitates enterotoxin-induced secretion from rat intestine.霍乱弧菌金属蛋白酶可降解肠道黏蛋白并促进肠毒素诱导的大鼠肠道分泌。
Biochim Biophys Acta. 1987 Jun 22;924(3):393-402. doi: 10.1016/0304-4165(87)90153-x.
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Prostaglandin E in cholera toxin-induced intestinal secretion. Lack of an intermediary role.前列腺素E在霍乱毒素诱导的肠道分泌中的作用。不存在中介作用。
Am J Dig Dis. 1975 Nov;20(11):1035-9. doi: 10.1007/BF01071191.
10
Specific binding of cholera toxin to isolated intestinal microvillous membranes.霍乱毒素与分离出的肠微绒毛膜的特异性结合。
Proc Natl Acad Sci U S A. 1974 Feb;71(2):320-4. doi: 10.1073/pnas.71.2.320.

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The superintegron integrase and the cassette promoters are co-regulated in Vibrio cholerae.霍乱弧菌中的超级整合子整合酶与盒式启动子存在共同调控。
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Identification of host cell factors required for intoxication through use of modified cholera toxin.利用改良型霍乱毒素鉴定致毒所需的宿主细胞因子。
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The role of mechanical forces and adenosine in the regulation of intestinal enterochromaffin cell serotonin secretion.机械力和腺苷在调节肠道嗜铬细胞 5-羟色胺分泌中的作用。
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Order-disorder-order transitions mediate the activation of cholera toxin.有序-无序-有序转变介导霍乱毒素的激活。
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本文引用的文献

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Molecular properties and transformations of glycogen phosphorylase in animal tissues.动物组织中糖原磷酸化酶的分子特性与转变
Adv Enzymol Relat Subj Biochem. 1962;24:263-90. doi: 10.1002/9780470124888.ch5.
2
ACTIVATION OF AN EPINEPHRINE-SENSITIVE LIPOLYTIC ACTIVITY FROM ADIPOSE TISSUE BY ADENOSINE 3',5'-PHOSPHATE.3',5'-磷酸腺苷对脂肪组织中肾上腺素敏感的脂解活性的激活作用
J Biol Chem. 1964 Feb;239:392-5.
3
Isolation of adenosine 3', 5'-monophosphate and guanosine 3', 5'-monophosphate from rat urine.从大鼠尿液中分离3',5'-环磷酸腺苷和3',5'-环磷酸鸟苷。
Biochem Biophys Res Commun. 1963 May 22;11:330-4. doi: 10.1016/0006-291x(63)90566-7.
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Laboratory Vibrio cholerae infection in the United States.美国的实验室霍乱弧菌感染
JAMA. 1966 Aug 1;197(5):321-6.
5
Preparation of the vascular permeability factor of Vibrio cholerae.霍乱弧菌血管通透性因子的制备
J Bacteriol. 1966 Sep;92(3):793-5. doi: 10.1128/jb.92.3.793-795.1966.
6
A permeability factor (toxin) found in cholera stools and culture filtrates and its neutralization by convalescent cholera sera.在霍乱粪便和培养滤液中发现的一种通透因子（毒素）及其被霍乱恢复期血清中和的情况。
Nature. 1965 Aug 7;207(997):614-6. doi: 10.1038/207614a0.
7
Time of onset of action of cholera toxin in dog and rabbit.霍乱毒素在犬和兔体内的起效时间。
Gastroenterology. 1969 Jul;57(1):5-8.
8
Site and characteristics of electrolyte loss and effect of intraluminal glucose in experimental canine cholera.实验性犬霍乱中电解质丢失的部位和特征以及肠腔内葡萄糖的作用
J Clin Invest. 1968 May;47(5):1210-20. doi: 10.1172/JCI105810.
9
Effects of vasopressin, theophylline and cyclic adenosine monophosphate on short-circuit current across isolated rabbit ileal mucosa.血管加压素、茶碱和环磷酸腺苷对离体兔回肠黏膜短路电流的影响。
Nature. 1968 Feb 3;217(5127):469-71. doi: 10.1038/217469a0.
10
Small bowel morphology in experimental canine cholera. A light and electron microscopic study.实验性犬霍乱的小肠形态学。光镜与电镜研究。
Lab Invest. 1970 Feb;22(2):112-20.

霍乱毒素处理后肠黏膜中3':5'-环磷酸腺苷浓度升高。

Elevated concentration of adenosine 3':5'-cyclic monophosphate in intestinal mucosa after treatment with cholera toxin.

作者信息

Schafer D E, Lust W D, Sircar B, Goldberg N D

出版信息

Proc Natl Acad Sci U S A. 1970 Oct;67(2):851-6. doi: 10.1073/pnas.67.2.851.

DOI:10.1073/pnas.67.2.851
PMID:4331724
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC283283/
Abstract

A heat-labile factor in cell-free filtrate of a Vibrio cholerae culture induces a marked rise in the wet-weight concentration of adenosine 3':5'-cyclic monophosphate (cyclic AMP) in the intestinal mucosa of the dog. The increase becomes appreciable 1-1.5 hr after intraluminal administration of the filtrate, about the same time as the onset of intestinal secretion in response to a heat-labile enterotoxin in the filtrate. These results are consistent with the hypothesis that cyclic AMP may be an intermediary in the intestinal secretory response to cholera toxin.

摘要

霍乱弧菌培养物的无细胞滤液中的一种热不稳定因子可使犬肠道黏膜中腺苷3':5'-环磷酸（环磷酸腺苷）的湿重浓度显著升高。在管腔内给予滤液后1 - 1.5小时，这种升高变得明显，这与滤液中热不稳定肠毒素引起的肠道分泌开始的时间大致相同。这些结果与环磷酸腺苷可能是肠道对霍乱毒素分泌反应的中间介质这一假说相一致。