Krystal G, Webb T E
Biochem J. 1971 Oct;124(5):943-7. doi: 10.1042/bj1240943.
Two species of uridine kinase with molecular weights of approximately 120000 (I) and 30000 (II) have been identified in the rat liver system. Species I predominates in the 7-day postnatal and adult rat liver and increases in the regenerating remnant of the latter after partial hepatectomy; the concentration of species II is low in these tissues. Species I also predominates in the slow-growing hepatomas 5123D and 7800. In contrast, II is the predominant form in the foetal rat liver and accounts for 40% of the total activity in the rapidly growing Novikoff ascites hepatoma. In contrast to species II, which was stable, species I was inactivated by preincubation for 30min at 37 degrees C, before assay at 23 degrees C.
在大鼠肝脏系统中已鉴定出两种分子量分别约为120000（I）和30000（II）的尿苷激酶。I型在出生后7天的大鼠肝脏和成年大鼠肝脏中占主导地位，在部分肝切除术后成年大鼠肝脏的再生残体中增加；II型在这些组织中的浓度较低。I型在生长缓慢的肝癌5123D和7800中也占主导地位。相比之下，II型是胎鼠肝脏中的主要形式，在快速生长的诺维科夫腹水肝癌中占总活性的40%。与稳定的II型不同，I型在37℃预孵育30分钟后，于23℃测定前被灭活。
