HeLa细胞中蛋白质合成的调控。3. 脊髓灰质炎病毒感染期间的抑制作用。
Regulation of protein synthesis in HeLa cells. 3. Inhibition during poliovirus infection.
作者信息
Leibowitz R, Penman S
出版信息
J Virol. 1971 Nov;8(5):661-8. doi: 10.1128/JVI.8.5.661-668.1971.
Abstract
The mechanism of inhibition of host cell protein synthesis by poliovirus has been studied by examining the behavior of host polyribosomes and polyribosome-associated messenger ribonucleic acid (mRNA). Virus infection appears to result in a specific inhibition of the initiation of translation of host cell mRNA. The site of inhibition does not appear to be mRNA itself. Human cells respond to virus infection by producing a factor antagonistic to the virus inhibition which promotes the initiation of host mRNA translation. The production of the host factor is sensitive to actinomycin; however, the behavior of the host cell factor and that of host mRNA appear distinctly different.
摘要
通过研究宿主多核糖体和与多核糖体相关的信使核糖核酸（mRNA）的行为，对脊髓灰质炎病毒抑制宿主细胞蛋白质合成的机制进行了研究。病毒感染似乎导致宿主细胞mRNA翻译起始的特异性抑制。抑制位点似乎不是mRNA本身。人类细胞通过产生一种与病毒抑制作用拮抗的因子来响应病毒感染，该因子促进宿主mRNA翻译的起始。宿主因子的产生对放线菌素敏感；然而，宿主细胞因子和宿主mRNA的行为明显不同。
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Control of specific gene expression in higher organisms. Expression of mammalian genes may be controlled by repressors acting on the translation of messenger RNA.高等生物中特定基因表达的调控。哺乳动物基因的表达可能受作用于信使核糖核酸翻译的阻遏物调控。
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