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HeLa细胞中蛋白质合成的调控。3. 脊髓灰质炎病毒感染期间的抑制作用。

Regulation of protein synthesis in HeLa cells. 3. Inhibition during poliovirus infection.

作者信息

Leibowitz R, Penman S

出版信息

J Virol. 1971 Nov;8(5):661-8. doi: 10.1128/JVI.8.5.661-668.1971.

DOI:10.1128/JVI.8.5.661-668.1971
PMID:4332137
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC376244/
Abstract

The mechanism of inhibition of host cell protein synthesis by poliovirus has been studied by examining the behavior of host polyribosomes and polyribosome-associated messenger ribonucleic acid (mRNA). Virus infection appears to result in a specific inhibition of the initiation of translation of host cell mRNA. The site of inhibition does not appear to be mRNA itself. Human cells respond to virus infection by producing a factor antagonistic to the virus inhibition which promotes the initiation of host mRNA translation. The production of the host factor is sensitive to actinomycin; however, the behavior of the host cell factor and that of host mRNA appear distinctly different.

摘要

通过研究宿主多核糖体和与多核糖体相关的信使核糖核酸（mRNA）的行为，对脊髓灰质炎病毒抑制宿主细胞蛋白质合成的机制进行了研究。病毒感染似乎导致宿主细胞mRNA翻译起始的特异性抑制。抑制位点似乎不是mRNA本身。人类细胞通过产生一种与病毒抑制作用拮抗的因子来响应病毒感染，该因子促进宿主mRNA翻译的起始。宿主因子的产生对放线菌素敏感；然而，宿主细胞因子和宿主mRNA的行为明显不同。

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Regulation of protein synthesis in HeLa cells. 3. Inhibition during poliovirus infection.HeLa细胞中蛋白质合成的调控。3. 脊髓灰质炎病毒感染期间的抑制作用。
J Virol. 1971 Nov;8(5):661-8. doi: 10.1128/JVI.8.5.661-668.1971.
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本文引用的文献

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Control of specific gene expression in higher organisms. Expression of mammalian genes may be controlled by repressors acting on the translation of messenger RNA.高等生物中特定基因表达的调控。哺乳动物基因的表达可能受作用于信使核糖核酸翻译的阻遏物调控。
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POLYRIBOSOMES IN NORMAL AND POLIOVIRUS-INFECTED HELA CELLS AND THEIR RELATIONSHIP TO MESSENGER-RNA.正常及脊髓灰质炎病毒感染的海拉细胞中的多核糖体及其与信使核糖核酸的关系
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INHIBITION OF HOST CELL MACROMOLECULAR SYNTHESIS BY HIGH MULTIPLICITIES OF POLIOVIRUS UNDER CONDITIONS PREVENTING VIRUS SYNTHESIS.在阻止病毒合成的条件下，高感染复数的脊髓灰质炎病毒对宿主细胞大分子合成的抑制作用
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Amino acid metabolism in mammalian cell cultures.哺乳动物细胞培养中的氨基酸代谢
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Effects of cycloheximide on polyribosome function in reticulocytes.放线菌酮对网织红细胞中多核糖体功能的影响。
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Use of low concentrations of actinomycin D in the study of RNA synthesis in Ehrlich ascites cells.低浓度放线菌素D在艾氏腹水癌细胞RNA合成研究中的应用。
J Mol Biol. 1966 Sep;20(1):63-73. doi: 10.1016/0022-2836(66)90117-3.
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RNA metabolism in the HeLa cell nucleus.海拉细胞核中的RNA代谢
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9
Regulation of protein synthesis in mammalian cells. II. Inhibition of protein synthesis at the level of initiation during mitosis.哺乳动物细胞中蛋白质合成的调控。II. 有丝分裂期间在起始水平对蛋白质合成的抑制。
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Regulation of protein synthesis in HeLa cells: translation at elevated temperatures.HeLa细胞中蛋白质合成的调控：高温下的翻译
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