大鼠抗血清对哺乳动物核糖核酸C型病毒脱氧核糖核酸聚合酶的特异性抑制作用。
Specific inhibition of mammalian ribonucleic acid C-type virus deoxyribonucleic acid polymerases by rat antisera.
作者信息
Oroszlan S, Hatanaka M, Gilden R V, Huebner R J
出版信息
J Virol. 1971 Nov;8(5):816-8. doi: 10.1128/JVI.8.5.816-818.1971.
Abstract
Inhibition of the ribonucleic acid (RNA)- and deoxyribonucleic acid (DNA)-dependent DNA polymerase activities of mammalian C-type viruses was obtained with sera from rats bearing murine leukemia virus-induced transplant tumors. Polymerase activities of nonmammalian (viper) C-type virus and murine mammary tumor virus were not inhibited by such sera nor by serum from a rat immunized with the DNA polymerase of feline leukemia virus purified by isoelectric focusing. The latter serum appeared to inhibit preferentially the DNA-dependent DNA polymerase activity of mammalian C-type viruses showing no inhibition of RNA-dependent DNA synthesis.
摘要
携带鼠白血病病毒诱导的移植肿瘤的大鼠血清可抑制哺乳动物C型病毒的核糖核酸（RNA）依赖性和脱氧核糖核酸（DNA）依赖性DNA聚合酶活性。非哺乳动物（蝰蛇）C型病毒和鼠乳腺肿瘤病毒的聚合酶活性不受此类血清抑制，用等电聚焦法纯化的猫白血病病毒DNA聚合酶免疫的大鼠血清也不能抑制其活性。后一种血清似乎优先抑制哺乳动物C型病毒的DNA依赖性DNA聚合酶活性，而对RNA依赖性DNA合成没有抑制作用。
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