核糖核酸肿瘤病毒逆转录酶的免疫学关系
Immunological relationships of reverse transcriptases from ribonucleic acid tumor viruses.
作者信息
Parks W P, Scolnick E M, Ross J, Todaro G J, Aaronson S A
出版信息
J Virol. 1972 Jan;9(1):110-5. doi: 10.1128/JVI.9.1.110-115.1972.
Abstract
Antiserum to partially purified reverse transcriptase from the Schmidt-Ruppin strain of Rous sarcoma virus has been prepared and characterized. Antibody to the avian polymerase inhibited the reverse transcriptase activity of avian C-type viruses but had no effect on the polymerase activity from C-type viruses of other classes. The known mammalian C-type viral polymerases were significantly inhibited only by the antiserum to murine C-type viral polymerases; reverse transcriptases from four other mammalian viruses were immunologically distinct from both avian and mammalian C-type viral polymerases. Partially purified murine leukemia viral DNA polymerase activity was comparably reduced by specific antibody regardless of the template used for enzyme detection.
摘要
已制备并鉴定了针对劳氏肉瘤病毒施密特 - 鲁平株部分纯化逆转录酶的抗血清。针对禽源聚合酶的抗体抑制了禽C型病毒的逆转录酶活性，但对其他类别的C型病毒的聚合酶活性没有影响。已知的哺乳动物C型病毒聚合酶仅被针对鼠C型病毒聚合酶的抗血清显著抑制；来自其他四种哺乳动物病毒的逆转录酶在免疫学上与禽源和哺乳动物C型病毒聚合酶均不同。无论用于酶检测的模板如何，特异性抗体均可同等程度地降低部分纯化的鼠白血病病毒DNA聚合酶活性。
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