巨噬细胞对结核分枝杆菌及其他生物体的血浆依赖性趋化作用。
Plasma-dependent chemotaxis of macrophages towards mycobacterium tuberculosis and other organisms.
作者信息
Symon D N, McKay I C, Wilkinson P C
出版信息
Immunology. 1972 Feb;22(2):267-76.
Heat-killed whole cells of activate normal fresh guinea-pig plasma so that a chemotactic factor which attracts guinea-pig macrophages is produced. This factor differs from that generated by endotoxin. Mycobacteria attract macrophages more strongly than neutrophils, while endotoxin attracts both types of cell strongly, but is more active for neutrophils than for macrophages. The activity of the mycobacterial cytotaxigen is found in several protein fractions and in other fractions extracted from whole organisms or culture filtrates and is still present after lipid has been removed from the bacterial cells. The capacity of to activate macrophage chemotaxis in plasma is dependent on a heat-labile factor in plasma and is abolished by treatment of the plasma with several complement inhibitors.
热灭活的[细菌名称]全细胞可激活正常新鲜豚鼠血浆，从而产生一种吸引豚鼠巨噬细胞的趋化因子。该因子与内毒素产生的因子不同。分枝杆菌比中性粒细胞更强烈地吸引巨噬细胞，而内毒素则强烈吸引这两种类型的细胞，但对中性粒细胞的活性比对巨噬细胞更高。分枝杆菌细胞趋化原的活性存在于几个蛋白质组分以及从整个生物体或培养滤液中提取的其他组分中，并且在从细菌细胞中去除脂质后仍然存在。[细菌名称]激活血浆中巨噬细胞趋化性的能力取决于血浆中的一种热不稳定因子，并且用几种补体抑制剂处理血浆后该能力被消除。
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