Friedrich K, Henning H
Z Gastroenterol. 1979 Mar;17(3):171-6.
The levels of cupriuresis before and after DL-Penicillamine have been investigated in 168 cases. The mean copper excretion before Penicillamine in chronic activ liver disease, chronic persistant hepatitis, cirrhosis and in transitional cases of aggressiv chronic hepatitis and primary biliary cirrhosis ranged from 29 gamma to 48 gamma/24 hr.; however, in some cases the daily copper excretion exceeds 100 gamma, as well in subjects with liver disease as in normals too. After ingesting 900 mg DL-Penicillamine the mean values of cupriuresis ranged from 500 gamma to 600 gamma/24 hr. Abnormal results were found in about 15% of those subjects with liver diseases; in only two of 20 cases with hypercupruria after Penicillamine Wilson's Disease was established.
对168例患者使用青霉胺前后的尿铜水平进行了研究。在慢性活动性肝病、慢性持续性肝炎、肝硬化以及侵袭性慢性肝炎和原发性胆汁性肝硬化的过渡病例中，服用青霉胺前的平均尿铜排泄量为29微克至48微克/24小时；然而，在一些病例中，无论是肝病患者还是正常人，每日尿铜排泄量都超过100微克。摄入900毫克青霉胺后，尿铜排泄的平均值为500微克至600微克/24小时。约15%的肝病患者出现异常结果；在服用青霉胺后出现高尿铜的20例病例中，仅2例确诊为威尔逊病。
