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[海马体在条件反射活动中的作用]

[Role of the hippocampus in conditioned reflex activity].

作者信息

Gambarian L S, Gekht K, Sarkisov G T, Koval' I N, Kazarian G M

出版信息

Zh Vyssh Nerv Deiat Im I P Pavlova. 1979 Jan-Feb;29(1):56-63.

PMID:433451
Abstract

The role of the hippocampus in animals' conditioned activity was studied in experiments on rats and cats with ablated hippocampus. It was shown that in rats the ablation leads to a statistically significant slowing down in learning of the avoidance reaction. The effect becomes stronger in stress situation. The process of learning and optimization of choice reaction in the maze with alimentary reinforcement if sharply impaired in rats with bilateral ablation of hippocampus. The bilateral ablation of the hippocampus in cats in experiments with choice of the side of the alimentary reinforcement prolonged the latencies and sharply increased the number of erroneous reactions. The obtained data are analyzed in terms of fronto-pallido-hippocampal system, which selects, compares and integrates sensory information at the stage of the afferent synthesis.

摘要

在对海马体被切除的大鼠和猫进行的实验中,研究了海马体在动物条件活动中的作用。结果表明,对于大鼠,海马体切除导致回避反应学习在统计学上显著减慢。在应激情况下,这种影响会更强。在有食物强化的迷宫中,双侧海马体切除的大鼠在学习和优化选择反应的过程中受到严重损害。在食物强化侧选择实验中,猫的双侧海马体切除延长了潜伏期,并大幅增加了错误反应的数量。根据额-苍白球-海马系统对所得数据进行了分析,该系统在传入综合阶段对感觉信息进行选择、比较和整合。

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