诱导核酸外切酶A能力有缺陷的噬菌体T4突变体的鉴定及遗传特征分析
Identification and genetic characterization of mutants of bacteriophage T4 defective in the ability to induce exonuclease A.
作者信息
Warner H R, Snustad D P, Koerner J F, Childs J D
出版信息
J Virol. 1972 Mar;9(3):399-407. doi: 10.1128/JVI.9.3.399-407.1972.
Abstract
A mutant of bacteriophage T4 unable to induce exonuclease A has been isolated. The mutation responsible for this defect maps between genes 39 and 56, in a region of the chromosome devoid of other known markers. Four deletion mutants lacking part of the genome located between genes 39 and 56 also fail to induce exonuclease A. The ability of all of these mutants to replicate suggests that exonuclease A is not essential for replication of phage T4.
摘要
一种无法诱导核酸外切酶A的噬菌体T4突变体已被分离出来。导致这种缺陷的突变位于基因39和56之间，在染色体的一个没有其他已知标记的区域。四个缺失了位于基因39和56之间部分基因组的缺失突变体也无法诱导核酸外切酶A。所有这些突变体的复制能力表明，核酸外切酶A对于噬菌体T4的复制并非必不可少。
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