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诱导核酸外切酶A能力有缺陷的噬菌体T4突变体的鉴定及遗传特征分析

Identification and genetic characterization of mutants of bacteriophage T4 defective in the ability to induce exonuclease A.

作者信息

Warner H R, Snustad D P, Koerner J F, Childs J D

出版信息

J Virol. 1972 Mar;9(3):399-407. doi: 10.1128/JVI.9.3.399-407.1972.

DOI:10.1128/JVI.9.3.399-407.1972
PMID:4335658
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC356312/
Abstract

A mutant of bacteriophage T4 unable to induce exonuclease A has been isolated. The mutation responsible for this defect maps between genes 39 and 56, in a region of the chromosome devoid of other known markers. Four deletion mutants lacking part of the genome located between genes 39 and 56 also fail to induce exonuclease A. The ability of all of these mutants to replicate suggests that exonuclease A is not essential for replication of phage T4.

摘要

一种无法诱导核酸外切酶A的噬菌体T4突变体已被分离出来。导致这种缺陷的突变位于基因39和56之间，在染色体的一个没有其他已知标记的区域。四个缺失了位于基因39和56之间部分基因组的缺失突变体也无法诱导核酸外切酶A。所有这些突变体的复制能力表明，核酸外切酶A对于噬菌体T4的复制并非必不可少。

相似文献

1
Identification and genetic characterization of mutants of bacteriophage T4 defective in the ability to induce exonuclease A.诱导核酸外切酶A能力有缺陷的噬菌体T4突变体的鉴定及遗传特征分析
J Virol. 1972 Mar;9(3):399-407. doi: 10.1128/JVI.9.3.399-407.1972.
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本文引用的文献

1
Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
2
THE LINKAGE MAP OF BACTERIOPHAGE T4.噬菌体T4的连锁图谱。
Genetics. 1964 Oct;50(4):539-52. doi: 10.1093/genetics/50.4.539.
3
A DEOXYRIBONUCLEASE INDUCED BY INFECTION WITH BACTERIOPHAGE T2.由噬菌体T2感染诱导产生的一种脱氧核糖核酸酶。
J Biol Chem. 1964 Sep;239:2935-43.
4
STUDIES ON LABILE DEOXYCYTIDYLATE HYDROXYMETHYLASES FROM ESCHERICHIA COLI B INFECTED WITH TEMPERATURE-SENSITIVE MUTANTS OF BACTERIOPHAGE T4.关于感染噬菌体T4温度敏感突变体的大肠杆菌B中不稳定脱氧胞苷酸羟甲基化酶的研究
Proc Natl Acad Sci U S A. 1964 Mar;51(3):421-8. doi: 10.1073/pnas.51.3.421.
5
Early enzyme synthesis and its control in E. coli infected with some amber mutants of bacteriophage T4.用噬菌体T4的一些琥珀突变体感染大肠杆菌后早期酶的合成及其调控
Proc Natl Acad Sci U S A. 1962 Feb;48(2):293-302. doi: 10.1073/pnas.48.2.293.
6
Automation of enzyme reactions: ribonuclease.
Anal Biochem. 1969 Jun;29(3):515-25. doi: 10.1016/0003-2697(69)90336-4.
7
A map of distances along the DNA molecule of phage T4.噬菌体T4 DNA分子上的距离图谱。
Genetics. 1968 Jun;59(2):137-51. doi: 10.1093/genetics/59.2.137.
8
Mutants in a nonessential gene of bacteriophage T4 which are defective in the degradation of Escherichia coli deoxyribonucleic acid.噬菌体T4非必需基因中的突变体，其在降解大肠杆菌脱氧核糖核酸方面存在缺陷。
J Virol. 1971 Jan;7(1):95-105. doi: 10.1128/JVI.7.1.95-105.1971.
9
The size of the rII region of bacteriophage T4.
Virology. 1970 Nov;42(3):717-23. doi: 10.1016/0042-6822(70)90317-x.
10
Separation and characterization of deoxyribonucleases of Escherichia coli B. I. Chromatographic separation and properties of two deoxyribo-oligonucleotidases.
J Biol Chem. 1966 Jul 10;241(13):3090-6.