噬菌体T5的遗传学和生理学研究。3. T5突变体诱导的脱氧核糖核酸合成模式以及对影响噬菌体诱导的二氢叶酸还原酶和脱氧核糖核酸酶出现的基因的鉴定。
Genetic and physiological studies of bacteriophage T5. 3. Patterns of deoxyribonucleic acid synthesis induced by mutants of T5 and the identification of genes influencing the appearance of phage-induced dihydrofolate reductase and deoxyribonuclease.
作者信息
Hendrickson H E, McCorquodale D J
出版信息
J Virol. 1972 Jun;9(6):981-9. doi: 10.1128/JVI.9.6.981-989.1972.
Abstract
Patterns of deoxyribonucleic acid (DNA) metabolism in nonpermissive cells infected with amber mutants representing 29 genes of T5 are reported. A group of 7 contiguous genes are essential for the synthesis of phage DNA, whereas 20 other genes, when defective, permit varying degrees of phage DNA synthesis. Two further genes are essential for complete transfer of phage DNA to host cells, and therefore indirectly do not permit the synthesis of phage DNA. The structural genes for an early T5 deoxyribonuclease and for T5 DNA polymerase, as well as a gene that affects the synthesis of dihydrofolate reductase, have been identified in the genetic map of T5.
摘要
本文报道了用代表T5噬菌体29个基因的琥珀突变体感染非允许细胞时脱氧核糖核酸（DNA）的代谢模式。一组7个相邻基因对于噬菌体DNA的合成至关重要，而另外20个基因有缺陷时，则允许不同程度的噬菌体DNA合成。还有两个基因对于噬菌体DNA完整转移到宿主细胞至关重要，因此间接不允许噬菌体DNA的合成。在T5噬菌体的遗传图谱中已经鉴定出一种早期T5脱氧核糖核酸酶和T5 DNA聚合酶的结构基因，以及一个影响二氢叶酸还原酶合成的基因。
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