• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

小鼠肝炎病毒在腹腔巨噬细胞中的多核细胞增多及复制

Polykaryocytosis and replication of mouse hepatitis virus in peritoneal macrophages.

作者信息

Lewis L, Starr T J

出版信息

Br J Exp Pathol. 1972 Apr;53(2):202-5.

PMID:4338061
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2072535/
Abstract

Results of this investigation indicated that the infectivity titre of mouse hepatitis virus decreased after 6 hour incubation at 37°. Nutrient fluids from infected macrophage cultures retained pathogenicity and the ability to form polykaryons Electron microscope studies of polykaryons formed from infected macrophage cultures showed the presence of virus-like particles in the cytoplasm. From the study, it was concluded that polykaryon formation in infected macrophage cultures resulted from an active viral agent.

摘要

本次调查结果表明，小鼠肝炎病毒的感染滴度在37℃孵育6小时后下降。来自受感染巨噬细胞培养物的营养液保留了致病性和形成多核体的能力。对受感染巨噬细胞培养物形成的多核体进行电子显微镜研究显示，细胞质中存在病毒样颗粒。从这项研究得出结论，受感染巨噬细胞培养物中多核体的形成是由一种活跃的病毒因子引起的。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fcc/2072535/22a698b24f0c/brjexppathol00416-0135-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fcc/2072535/bc47793f39c7/brjexppathol00416-0136-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fcc/2072535/22a698b24f0c/brjexppathol00416-0135-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fcc/2072535/bc47793f39c7/brjexppathol00416-0136-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fcc/2072535/22a698b24f0c/brjexppathol00416-0135-a.jpg

相似文献

1
Polykaryocytosis and replication of mouse hepatitis virus in peritoneal macrophages.小鼠肝炎病毒在腹腔巨噬细胞中的多核细胞增多及复制
Br J Exp Pathol. 1972 Apr;53(2):202-5.
2
Effects of hydrocortisone on murine hepatitis virus replication and cell injury in cultured liver cells and macrophages.
Am J Gastroenterol. 1972 Jun;57(6):485-519.
3
Correlation of persistent mouse hepatitis virus (MHV-3) infection with its effect on mouse macrophage cultures.持续性小鼠肝炎病毒（MHV-3）感染与其对小鼠巨噬细胞培养物影响的相关性。
Arch Virol. 1976;50(4):279-85. doi: 10.1007/BF01317953.
4
Influence of the cytoskeleton on the expression of a mouse hepatitis virus (MHV-3) in peritoneal macrophages: acute and persistent infection.
J Gen Virol. 1982 Nov;63 (Pt 1):217-21. doi: 10.1099/0022-1317-63-1-217.
5
Electron microscopy of tissue culture cells infected with myxoviruses. II. Nucleo-cytoplasmic changes in fowl plague virus-infected cells.感染黏液病毒的组织培养细胞的电子显微镜观察。II. 感染禽瘟病毒细胞的核质变化
Acta Virol. 1972 May;16(3):177-82.
6
[Electron microscopic studies of the effect of streptomycete antibiotic borrelidin on the pseudorabies virus].
Z Allg Mikrobiol. 1973;13(8):711-22.
7
Low-virulent mouse hepatitis viruses exhibiting various tropisms in macrophages, T and B cell subpopulations, and thymic stromal cells.低毒力小鼠肝炎病毒在巨噬细胞、T和B细胞亚群以及胸腺基质细胞中表现出不同的嗜性。
Lab Anim Sci. 1994 Feb;44(1):17-24.
8
[In vitro study of the interaction of rubeola virus with the peritoneal macrophages of unimmunized and immunized rats].[麻疹病毒与未免疫和免疫大鼠腹膜巨噬细胞相互作用的体外研究]
Rev Cubana Med Trop. 1980 Sep-Dec;32(3):204-10.
9
Bone-marrow derived macrophages as targets for the replication of mouse hepatitis virus type 3.骨髓来源的巨噬细胞作为3型小鼠肝炎病毒的复制靶标。
Immunol Lett. 1983;7(2):107-10. doi: 10.1016/0165-2478(83)90042-1.
10
Infection of Hela cells with a virulent and an attenuated strain of pseudorabies virus studied by electron microscopy.通过电子显微镜研究强毒株和减毒株伪狂犬病病毒对海拉细胞的感染。
Acta Virol. 1976 Jun;20(3):247-9.

本文引用的文献

1
Conversion of genetic resistance of mammalian cells to susceptibility to a virus infection.哺乳动物细胞的遗传抗性向病毒感染易感性的转变。
Proc Natl Acad Sci U S A. 1962 Sep 15;48(9):1553-9. doi: 10.1073/pnas.48.9.1553.
2
AN ELECTRON MICROSCOPE STUDY OF THE DEVELOPMENT OF A MOUSE HEPATITIS VIRUS IN TISSUE CULTURE CELLS.小鼠肝炎病毒在组织培养细胞中发育的电子显微镜研究
J Cell Biol. 1965 Jan;24(1):57-78. doi: 10.1083/jcb.24.1.57.
3
OBSERVATIONS ON THE GROWTH OF MOUSE HEPATITIS VIRUS (MHV-3) IN MOUSE MACROPHAGES.小鼠巨噬细胞中鼠肝炎病毒（MHV-3）生长情况的观察
Virology. 1965 Jan;25:30-7. doi: 10.1016/0042-6822(65)90248-5.
4
THE DIFFERENTIATION OF MONONUCLEAR PHAGOCYTES. MORPHOLOGY, CYTOCHEMISTRY, AND BIOCHEMISTRY.单核吞噬细胞的分化。形态学、细胞化学与生物化学
J Exp Med. 1965 Jan 1;121(1):153-70. doi: 10.1084/jem.121.1.153.
5
Mouse hepatitis virus and its pathogenic action.小鼠肝炎病毒及其致病作用。
J Pathol Bacteriol. 1955 Jan-Apr;69(1-2):299-309. doi: 10.1002/path.1700690138.
6
Relationship of phagocytic activity to pathogenicity of mouse hepatitis virus as affected by triolein and cortisone.三油酸甘油酯和可的松对小鼠肝炎病毒吞噬活性与致病性之间关系的影响
Br J Exp Pathol. 1969 Oct;50(5):475-80.
7
Plaque assay for mouse hepatitis virus (MHV-2) on primary macrophage cell cultures.在原代巨噬细胞培养物上对小鼠肝炎病毒（MHV - 2）进行蚀斑测定。
Proc Soc Exp Biol Med. 1966 Mar;121(3):829-31. doi: 10.3181/00379727-121-30899.