5,6-反式-25-羟基胆钙化醇：对无肾大鼠肠道有效的维生素D类似物。
5,6-Trans-25-hydroxycholecalciferol: vitamin D analog effective on intestine of anephric rats.
作者信息
Holick M F, Garabedian M, DeLuca H F
出版信息
Science. 1972 Jun 16;176(4040):1247-8. doi: 10.1126/science.176.4040.1247.
PMID:4338253
Abstract
A new compound, 5,6-trans-25-hydroxycholecalciferol, has been synthesized and tested for its biological activity. Like 1,25-dihydroxycholecalciferol, it stimulates intestinal calcium transport in anephric rats, whereas 25-hydroxycholecalciferol does not. But this analog has little if any activity in stimulating mobilization of calcium from the bone of anephric rats.
摘要
一种新的化合物，5,6-反式-25-羟基胆钙化醇，已被合成并测试其生物活性。与1,25-二羟基胆钙化醇一样，它能刺激无肾大鼠的肠道钙转运，而25-羟基胆钙化醇则不能。但这种类似物在刺激无肾大鼠骨骼中的钙动员方面几乎没有活性。
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