Whitmire C E, Huebner R J
Science. 1972 Jul 7;177(4043):60-1. doi: 10.1126/science.177.4043.60.
The incidence of 3-methylcholanthrene-induced subcutaneous tumors was significantly reduced by a single injection of inactivated type C RNA viral vaccine. Rauscher leukemia virus vaccine reduced the incidence of sarcomas from 78 to 50 percent in the BALB/cCr mouse. Radiation leukemia virus vaccine and a vaccine from a wild murine leukemia virus derived from a 3-methylcholanthrene tumor reduced the incidence of sarcoma from 86 percent to 33 and 37 percents, respectively, in the C57BL/6 mouse. These reductions in tumor incidence by virus vaccines help support the concept that type C RNA viruses serve as determinants of chemically induced cancer; additional studies of vaccines made with more purified virus preparations are necessary.
单次注射灭活的C型RNA病毒疫苗可显著降低3-甲基胆蒽诱导的皮下肿瘤的发生率。劳斯氏白血病病毒疫苗使BALB/cCr小鼠肉瘤的发生率从78%降至50%。辐射白血病病毒疫苗以及源自3-甲基胆蒽肿瘤的野生鼠白血病病毒制成的疫苗，分别使C57BL/6小鼠肉瘤的发生率从86%降至33%和37%。病毒疫苗对肿瘤发生率的这些降低作用有助于支持C型RNA病毒是化学诱导癌症的决定因素这一概念；有必要对用更纯化的病毒制剂制成的疫苗进行更多研究。
