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1
Suppression of murine type-C RNA virogenes by type-specific oncornavirus vaccines: prospects for prevention of cancer.通过型特异性肿瘤病毒疫苗抑制小鼠C型RNA病毒基因：癌症预防的前景
Proc Natl Acad Sci U S A. 1976 Feb;73(2):620-4. doi: 10.1073/pnas.73.2.620.
2
Prevention of spontaneous leukemia in AKR mice by type-specific immunosuppression of endogenous ecotropic virogenes.通过对内源性嗜亲性病毒基因进行型特异性免疫抑制预防AKR小鼠自发性白血病。
Proc Natl Acad Sci U S A. 1976 Dec;73(12):4633-5. doi: 10.1073/pnas.73.12.4633.
3
Immunoprevention of naturally occurring endogenous murine type-C RNA viruses.
Nature. 1978 Jun 1;273(5661):383-5. doi: 10.1038/273383a0.
4
[Protein composition and immunologic properties of type C oncornavirus from spontaneous lymphosarcoma of mouse strain CC57/Br (OP virus)].[来自CC57/Br小鼠品系自发性淋巴肉瘤的C型肿瘤病毒的蛋白质组成和免疫特性（OP病毒）]
Vopr Virusol. 1977 May-Jun(3):354-9.
5
Prevention of spontaneous leukemia in mice by oncornavirus immunization.通过肿瘤病毒免疫预防小鼠自发性白血病。
Int J Cancer. 1979 Feb;23(2):269-73. doi: 10.1002/ijc.2910230219.
6
Purification and analysis of a Gross murine oncornavirus protein with a molecular weight of about 12,000 specific for the Gross virus subgroup.对一种分子量约为12,000、对格罗斯病毒亚组具有特异性的格罗斯小鼠肿瘤病毒蛋白进行纯化和分析。
Virology. 1977 Jun 1;79(1):129-43. doi: 10.1016/0042-6822(77)90340-3.
7
The antibody response of mice to murine leukemia virus in spontaneous infection: absence of classical immunologic tolerance (AKR mice-complement-fixing antibodies-lymphocytic choriomeningitis virus-immunofluorescence-glomerular deposits of antigen-antibody complexes).小鼠在自然感染中对鼠白血病病毒的抗体反应：缺乏经典免疫耐受性（AKR小鼠-补体结合抗体-淋巴细胞性脉络丛脑膜炎病毒-免疫荧光-抗原抗体复合物的肾小球沉积物）
Proc Natl Acad Sci U S A. 1972 Jan;69(1):134-8. doi: 10.1073/pnas.69.1.134.
8
The humoral immune response of NIH Swiss and SWR/J mice to vaccination with formalinized AKR or Gross murine leukemia virus.NIH瑞士小鼠和SWR/J小鼠对用福尔马林处理的AKR或格罗斯鼠白血病病毒疫苗接种的体液免疫反应。
Proc Natl Acad Sci U S A. 1977 Jan;74(1):343-7. doi: 10.1073/pnas.74.1.343.
9
Immune complexes localized in the renal glomeruli of AKR mice: the presence of MuLV gs-I and C-type RNA tumor virus gs-3 determinants.定位在AKR小鼠肾小球中的免疫复合物：莫氏白血病病毒gs-I和C型RNA肿瘤病毒gs-3决定簇的存在。
Rev Eur Etud Clin Biol. 1972 Aug-Sep;17(7):690-4.
10
Expression of CTL-defined, AKR/Gross retrovirus-associated tumor antigens by normal spleen cells: control by Fv-1, H-2, and proviral genes and effect on antiviral CTL generation.正常脾细胞对CTL定义的、与AKR/Gross逆转录病毒相关肿瘤抗原的表达：受Fv-1、H-2和前病毒基因的调控及其对抗病毒CTL产生的影响
J Immunol. 1986 Jan;136(1):308-12.

引用本文的文献

1
Kinetics of expression of infectious ecotropic, xenotropic, and mink cell focus-forming murine leukemia virus after 5-iododeoxyuridine induction of cells from high- and low-leukemia mouse strains.用5-碘脱氧尿苷诱导高白血病和低白血病小鼠品系的细胞后，感染性亲嗜性、异嗜性和貂细胞集落形成性鼠白血病病毒的表达动力学
J Virol. 1983 Feb;45(2):755-65. doi: 10.1128/JVI.45.2.755-765.1983.
2
Immunization against primary, transplanted and spontaneous murine leukaemia using a live Moloney sarcoma virus vaccine.使用活的莫洛尼肉瘤病毒疫苗对原发性、移植性和自发性小鼠白血病进行免疫接种。
Br J Cancer. 1980 Jun;41(6):966-75. doi: 10.1038/bjc.1980.175.
3
Effect of chemical modification and fragmentation on antigenic determinants of internal protein p30 and surface glycoprotein gp70 of type C retroviruses.化学修饰和片段化对C型逆转录病毒内部蛋白p30和表面糖蛋白gp70抗原决定簇的影响。
J Virol. 1980 Mar;33(3):983-92. doi: 10.1128/JVI.33.3.983-992.1980.
4
Antigenic modulation of Friend virus erythroleukemic cells in vitro by serum from mice with dormant erythroleukemia.来自患有潜伏性红白血病小鼠的血清对体外培养的弗氏病毒红白血病细胞的抗原调制作用。
J Exp Med. 1977 Aug 1;146(2):520-34. doi: 10.1084/jem.146.2.520.
5
Specificity of response to viral proteins in horses infected with equine infectious anemia virus.感染马传染性贫血病毒的马匹对病毒蛋白反应的特异性
Infect Immun. 1979 Feb;23(2):472-8. doi: 10.1128/iai.23.2.472-478.1979.
6
Suppression of leukemogenesis in hairless mice by anti-type C viral immune gamma globulins.抗C型病毒免疫γ球蛋白对无毛小鼠白血病发生的抑制作用。
Naturwissenschaften. 1978 Aug;65(8):443-4. doi: 10.1007/BF00405379.
7
Immunoprevention of x-ray-induced leukemias in the C57BL mouse.C57BL小鼠中X射线诱导白血病的免疫预防
Proc Natl Acad Sci U S A. 1977 Apr;74(4):1697-701. doi: 10.1073/pnas.74.4.1697.
8
Prevention of spontaneous leukemia in AKR mice by type-specific immunosuppression of endogenous ecotropic virogenes.通过对内源性嗜亲性病毒基因进行型特异性免疫抑制预防AKR小鼠自发性白血病。
Proc Natl Acad Sci U S A. 1976 Dec;73(12):4633-5. doi: 10.1073/pnas.73.12.4633.

本文引用的文献

1
Biological studies on a lymphoid-leukemia virus extracted from sarcoma 37. I. Origin and introductory investigations.从肉瘤37中提取的一种淋巴白血病病毒的生物学研究。I. 起源与初步研究。
J Natl Cancer Inst. 1960 Apr;24:933-51.
2
IMMUNE REACTIONS TO A MURINE LEUKEMIA VIRUS. I. INDUCTION OF IMMUNITY TO INFECTION WITH VIRUS IN THE NATURAL HOST.对一种小鼠白血病病毒的免疫反应。I. 在自然宿主中诱导对病毒感染的免疫力。
J Natl Cancer Inst. 1964 May;32:1075-82.
3
Immunological relationships of a filterable agent causing a leukemia in adult mice. I. The neutralization of infectivity by specific antiserum.一种可滤过因子在成年小鼠中引发白血病的免疫学关系。I. 特异性抗血清对感染性的中和作用。
J Exp Med. 1959 Feb 1;109(2):217-28. doi: 10.1084/jem.109.2.217.
4
Passive and active immunity to Friend virus disease.对弗氏病毒病的被动免疫和主动免疫。
Nature. 1966 Feb 12;209(5024):696-8. doi: 10.1038/209696a0.
5
Purification, concentration, and inactivation of Venezuelan equine encephalitis virus.委内瑞拉马脑炎病毒的纯化、浓缩及灭活
Appl Microbiol. 1970 Sep;20(3):427-32. doi: 10.1128/am.20.3.427-432.1970.
6
Maternal vaccination with formalin-inactivated Gross lymphoma virus in rats and transfer of immunity to offspring.用福尔马林灭活的大鼠大淋巴瘤病毒对母体进行疫苗接种并将免疫力传递给后代。
Proc Soc Exp Biol Med. 1973 Nov;144(2):376-9. doi: 10.3181/00379727-144-37595.
7
Hereditary immunodeficiency and leukemogenesis in HRS-J mice.HRS-J小鼠中的遗传性免疫缺陷与白血病发生
Cancer Res. 1974 Jan;34(1):201-11.
8
Biophysical-immunological assay for ribonucleic acid type C viruses.丙型核糖核酸病毒的生物物理免疫测定法。
Appl Microbiol. 1974 Jul;28(1):100-5. doi: 10.1128/am.28.1.100-105.1974.
9
Autogenous immunity to endogenous RNA tumor virus. Identification of antibody reactivity to select viral antigens.对内源性RNA肿瘤病毒的自身免疫。对选定病毒抗原的抗体反应性鉴定。
J Exp Med. 1974 Jun 1;139(6):1568-81. doi: 10.1084/jem.139.6.1568.
10
Virus-chemical carcinogenesis: a possible viral immunologic influence on 3-methylcholanthrene sarcoma induction.病毒-化学致癌作用：病毒免疫对3-甲基胆蒽肉瘤诱导可能产生的影响。
J Natl Cancer Inst. 1973 Aug;51(2):473-8.

通过型特异性肿瘤病毒疫苗抑制小鼠C型RNA病毒基因：癌症预防的前景

Suppression of murine type-C RNA virogenes by type-specific oncornavirus vaccines: prospects for prevention of cancer.

作者信息

Huebner R J, Gilden R V, Lane W T, Toni R, Trimmer R W, Hill P R

出版信息

Proc Natl Acad Sci U S A. 1976 Feb;73(2):620-4. doi: 10.1073/pnas.73.2.620.

DOI:10.1073/pnas.73.2.620
PMID:174116
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC335963/
Abstract

Immunization of crossbred and F1 mice with combined killed and live Gross leukemia virus AKR type-C viral vaccines suppressed endogeneous N-type AKR virus up to 10,000-fold for significant periods during early life. Since several previous studies in the same and similar crossbred systems revealed direct correlations between low and high levels of type-C virus early in life with low and high incidences of leukemia and other cancers later in life, we believe that prospects for suppression of spontaneous neoplasms are good; however, 8-14 months will be required to achieve the final results. Should cancers be prevented by serotype-specific vaccines, such evidence would provide conclusive proof of endogenous viral etiology.

摘要

用灭活和活的格罗斯白血病病毒AKR-C型病毒联合疫苗对杂交和F1代小鼠进行免疫接种，在其生命早期的相当长一段时间内，可将内源性N型AKR病毒抑制达10000倍。由于此前在相同及类似杂交系统中的多项研究表明，生命早期C型病毒水平的高低与后期白血病及其他癌症的发病率高低直接相关，我们认为抑制自发肿瘤的前景良好；然而，要取得最终结果还需要8至14个月。如果血清型特异性疫苗能够预防癌症，此类证据将为内源性病毒病因提供确凿证明。