通过型特异性肿瘤病毒疫苗抑制小鼠C型RNA病毒基因：癌症预防的前景
Suppression of murine type-C RNA virogenes by type-specific oncornavirus vaccines: prospects for prevention of cancer.
作者信息
Huebner R J, Gilden R V, Lane W T, Toni R, Trimmer R W, Hill P R
出版信息
Proc Natl Acad Sci U S A. 1976 Feb;73(2):620-4. doi: 10.1073/pnas.73.2.620.
Abstract
Immunization of crossbred and F1 mice with combined killed and live Gross leukemia virus AKR type-C viral vaccines suppressed endogeneous N-type AKR virus up to 10,000-fold for significant periods during early life. Since several previous studies in the same and similar crossbred systems revealed direct correlations between low and high levels of type-C virus early in life with low and high incidences of leukemia and other cancers later in life, we believe that prospects for suppression of spontaneous neoplasms are good; however, 8-14 months will be required to achieve the final results. Should cancers be prevented by serotype-specific vaccines, such evidence would provide conclusive proof of endogenous viral etiology.
摘要
用灭活和活的格罗斯白血病病毒AKR-C型病毒联合疫苗对杂交和F1代小鼠进行免疫接种，在其生命早期的相当长一段时间内，可将内源性N型AKR病毒抑制达10000倍。由于此前在相同及类似杂交系统中的多项研究表明，生命早期C型病毒水平的高低与后期白血病及其他癌症的发病率高低直接相关，我们认为抑制自发肿瘤的前景良好；然而，要取得最终结果还需要8至14个月。如果血清型特异性疫苗能够预防癌症，此类证据将为内源性病毒病因提供确凿证明。
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Suppression of murine type-C RNA virogenes by type-specific oncornavirus vaccines: prospects for prevention of cancer.通过型特异性肿瘤病毒疫苗抑制小鼠C型RNA病毒基因：癌症预防的前景
Proc Natl Acad Sci U S A. 1976 Feb;73(2):620-4. doi: 10.1073/pnas.73.2.620.
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Maternal vaccination with formalin-inactivated Gross lymphoma virus in rats and transfer of immunity to offspring.用福尔马林灭活的大鼠大淋巴瘤病毒对母体进行疫苗接种并将免疫力传递给后代。
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