预防内源性大鼠逆转录病毒预接种大鼠中3-甲基胆蒽诱导的纤维肉瘤。

Prevention of 3-methylcholanthrene-induced fibrosarcomas in rats pre-inoculated with endogenous rat retrovirus.

作者信息

Fish D C, Demarais J T, Djurickovic D B, Huebner R J

出版信息

Proc Natl Acad Sci U S A. 1981 Apr;78(4):2526-7. doi: 10.1073/pnas.78.4.2526.

DOI:10.1073/pnas.78.4.2526

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC319380/

Abstract

Weanling Fischer 344 rats received a single intraperitoneal injection of a 1000-fold concentrated preparation of endogenous nontransforming rat retrovirus. Ten days later, the rats were each given a single subcutaneous injection of 3-methylcholanthrene. The rats inoculated with the endogenous rat retrovirus were significantly protected against the development of cancer, whereas uninoculated rats and rats given one of several murine retroviruses or baboon retrovirus were not protected.

摘要

断乳期的费希尔344大鼠接受了一次腹腔注射内源性非转化大鼠逆转录病毒的1000倍浓缩制剂。10天后，每只大鼠接受一次皮下注射3-甲基胆蒽。接种内源性大鼠逆转录病毒的大鼠在预防癌症发生方面得到了显著保护，而未接种的大鼠以及接种了几种鼠逆转录病毒或狒狒逆转录病毒之一的大鼠则未得到保护。

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2

Virus-chemical carcinogenesis: a possible viral immunologic influence on 3-methylcholanthrene sarcoma induction.病毒-化学致癌作用：病毒免疫对3-甲基胆蒽肉瘤诱导可能产生的影响。

J Natl Cancer Inst. 1973 Aug;51(2):473-8.

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Inhibition of chemical carcinogenesis by viral vaccines.病毒疫苗对化学致癌作用的抑制

Science. 1972 Jul 7;177(4043):60-1. doi: 10.1126/science.177.4043.60.

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Virology. 1977 Jun 1;79(1):239-43. doi: 10.1016/0042-6822(77)90349-x.

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