肿瘤细胞中胎儿抗原的表达。
Expression of fetal antigens in tumor cells.
作者信息
Ting C C, Lavrin D H, Shiu G, Herberman R B
出版信息
Proc Natl Acad Sci U S A. 1972 Jul;69(7):1664-8. doi: 10.1073/pnas.69.7.1664.
The activities of sera that reacted specifically with the specific cell-surface antigens of polyoma or simian virus 40 tumors could only be inhibited by absorption of the sera with tumor cells transformed by the specific virus, and could not be removed by the absorption with cells from various fetal tissues nor with cells from other tumors. In contrasts, the antisera produced in male C3H/HeN mice by inoculation of irradiated, syngeneic fetal tissue of 1- to 2-weeks gestation, reacted with various tumor cells. The activities of these sera, when tested against cells from tumors induced by polyoma virus or simian virus 40, could also be removed by absorption with cells from tumors induced by viruses other than polyoma or simian virus 40, including leukemia cells induced by Gross virus (C58NT)D, Rauscher virus (RBL-5), and by dimethylbenzanthrene (EL. 4), and cells from mammary tumors (MM102), plasma-cell tumors (MPC-113), and fetal tissues. These results indicated that fetal antigens may be expressed in tumor cells, but they are different from tumor-specific antigens that are specific for a particular tumor or for tumors induced by a particular virus.
与多瘤病毒或猿猴病毒40肿瘤的特定细胞表面抗原发生特异性反应的血清活性，只能通过用特定病毒转化的肿瘤细胞吸收血清来抑制，而不能通过用来自各种胎儿组织的细胞或其他肿瘤的细胞吸收来去除。相比之下，雄性C3H/HeN小鼠通过接种妊娠1至2周的经辐射的同基因胎儿组织产生的抗血清，能与各种肿瘤细胞发生反应。当用这些血清检测多瘤病毒或猿猴病毒40诱导的肿瘤细胞时，其活性也可以通过用除多瘤病毒或猿猴病毒40以外的病毒诱导的肿瘤细胞吸收来去除，这些病毒包括格罗斯病毒（C58NT）D、劳舍尔病毒（RBL-5）和二甲基苯并蒽（EL. 4）诱导的白血病细胞，以及乳腺肿瘤（MM102）、浆细胞瘤（MPC-113）和胎儿组织的细胞。这些结果表明，胎儿抗原可能在肿瘤细胞中表达，但它们不同于特定肿瘤或特定病毒诱导的肿瘤所特有的肿瘤特异性抗原。
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