Vengris V E, Maré C J
Can J Comp Med. 1972 Jul;36(3):288-93.
The production of interferon by pigs in response to viral and synthetic inducers was studied. The inducers used included polyriboinosinic-polyribocytidylic acid (Poly I:C), swine influenza virus and pseudorabies virus. Following intravenous inoculation of pigs with the inducers, sera were examined for interferon by the plaque-reduction method in porcine kidney (PK(15)) cell cultures using vesicular stomatitis virus as the challenge inoculum. It was shown that pigs can produce interferon in response to each of these inducers. The pseudorabies virus used in this investigation was found to be a better interferon inducer than the swine influenza virus. The interferon produced in pigs was identified as an interferon because it was pH stable, non-dialyzable, sensitive to trypsin, non-sedimentable and possessed broad-spectrum antiviral activity as well as host-species specificity.
研究了猪对病毒诱导剂和合成诱导剂产生干扰素的情况。所用的诱导剂包括聚肌苷酸-聚胞苷酸（Poly I:C）、猪流感病毒和伪狂犬病病毒。给猪静脉接种诱导剂后，采用蚀斑减少法，以水疱性口炎病毒作为攻击接种物，在猪肾（PK(15)）细胞培养物中检测血清中的干扰素。结果表明，猪对每种诱导剂都能产生干扰素。本研究中使用的伪狂犬病病毒被发现是比猪流感病毒更好的干扰素诱导剂。猪产生的干扰素被鉴定为干扰素，因为它对pH稳定、不可透析、对胰蛋白酶敏感、不可沉淀，并且具有广谱抗病毒活性以及宿主物种特异性。
