Baum S G, Horwitz M S, Maizel J V
J Virol. 1972 Aug;10(2):211-9. doi: 10.1128/JVI.10.2.211-219.1972.
The defect which prevents human adenovirus replication in monkey cells and the mechanism whereby this restriction is overcome by coinfection with simian virus 40 (SV40) have been studied. Adenovirus capsid proteins are not synthesized efficiently in monkey cells in the absence of SV40. Adenovirus "enhancement" by SV40 was found to be the product of increased efficiency of replication by a small percentage of cells. This enhancement effect apparently occurred only when SV40 and adenovirus infected the same cells. These findings suggest that the replicative block occurs prior to virion assembly, and an accompanying report seeks to locate the site of restriction more precisely at the post-transcriptional level.
对阻止人腺病毒在猴细胞中复制的缺陷以及通过与猿猴病毒40（SV40）共感染克服这种限制的机制进行了研究。在没有SV40的情况下，腺病毒衣壳蛋白在猴细胞中不能有效合成。发现SV40对腺病毒的“增强作用”是一小部分细胞复制效率提高的产物。这种增强作用显然仅在SV40和腺病毒感染同一细胞时才会发生。这些发现表明复制障碍发生在病毒体组装之前，并且一篇附带报告试图在转录后水平更精确地定位限制位点。
