Plummer G, Coleman P L, Henson D
Infect Immun. 1972 Feb;5(2):172-5. doi: 10.1128/iai.5.2.172-175.1972.
The spinal cords of rabbits were chronically infected by a slowly growing horse herpesvirus (a "cytomegalovirus") inoculated directly therein. Virus was recovered from the central nervous systems of some of such animals after more than 1 year. The virus could be reisolated from all the animals killed during the first few weeks after its injection; acute focal meningomyelitis was present with involvement of gray and white matter of the cervical, thoracic, and lumbar levels of the spinal cords of these rabbits, though the nerve cells themselves remained undamaged. Thereafter, reisolation of the virus became sporadic, and no damage to the spinal cord could be histologically discerned even in animals from which the virus was recovered. No paralytic or other clinical effects could be attributed to the infection.
将马疱疹病毒(一种“巨细胞病毒”)直接接种到兔子脊髓中,使其受到慢性感染。1年多后,从其中一些动物的中枢神经系统中分离出了病毒。在注射病毒后的最初几周内处死的所有动物中都能重新分离出病毒;这些兔子的颈、胸和腰段脊髓的灰质和白质受累,出现急性局灶性脑脊膜炎,不过神经细胞本身未受损。此后,病毒的重新分离变得不那么频繁,即使在病毒检测呈阳性的动物中,脊髓也未发现组织学损伤。感染未导致麻痹或其他临床症状。