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一种生长缓慢的马疱疹病毒对兔中枢神经系统的慢性感染。

Chronic infection of the rabbit central nervous system by a slowly growing equine herpesvirus.

作者信息

Plummer G, Coleman P L, Henson D

出版信息

Infect Immun. 1972 Feb;5(2):172-5. doi: 10.1128/iai.5.2.172-175.1972.

DOI:10.1128/iai.5.2.172-175.1972
PMID:4344089
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC422343/
Abstract

The spinal cords of rabbits were chronically infected by a slowly growing horse herpesvirus (a "cytomegalovirus") inoculated directly therein. Virus was recovered from the central nervous systems of some of such animals after more than 1 year. The virus could be reisolated from all the animals killed during the first few weeks after its injection; acute focal meningomyelitis was present with involvement of gray and white matter of the cervical, thoracic, and lumbar levels of the spinal cords of these rabbits, though the nerve cells themselves remained undamaged. Thereafter, reisolation of the virus became sporadic, and no damage to the spinal cord could be histologically discerned even in animals from which the virus was recovered. No paralytic or other clinical effects could be attributed to the infection.

摘要

将马疱疹病毒(一种“巨细胞病毒”)直接接种到兔子脊髓中,使其受到慢性感染。1年多后,从其中一些动物的中枢神经系统中分离出了病毒。在注射病毒后的最初几周内处死的所有动物中都能重新分离出病毒;这些兔子的颈、胸和腰段脊髓的灰质和白质受累,出现急性局灶性脑脊膜炎,不过神经细胞本身未受损。此后,病毒的重新分离变得不那么频繁,即使在病毒检测呈阳性的动物中,脊髓也未发现组织学损伤。感染未导致麻痹或其他临床症状。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/96d2/422343/6ecc20cecffc/iai00266-0024-d.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/96d2/422343/86b8628ec5b2/iai00266-0024-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/96d2/422343/6693c7a97ed3/iai00266-0024-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/96d2/422343/ba22f6ba4fbc/iai00266-0024-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/96d2/422343/6ecc20cecffc/iai00266-0024-d.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/96d2/422343/86b8628ec5b2/iai00266-0024-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/96d2/422343/6693c7a97ed3/iai00266-0024-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/96d2/422343/ba22f6ba4fbc/iai00266-0024-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/96d2/422343/6ecc20cecffc/iai00266-0024-d.jpg

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Chronic infection of the rabbit central nervous system by a slowly growing equine herpesvirus.一种生长缓慢的马疱疹病毒对兔中枢神经系统的慢性感染。
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引用本文的文献

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The latent herpes simplex virus.潜伏性单纯疱疹病毒
Bacteriol Rev. 1974 Dec;38(4):337-55. doi: 10.1128/br.38.4.337-355.1974.
2
Animal cytomegaloviruses.动物巨细胞病毒
Microbiol Rev. 1990 Sep;54(3):247-65. doi: 10.1128/mr.54.3.247-265.1990.

本文引用的文献

1
Chronic infections by herpes simplex viruses and by the horse and cat herpesviruses.单纯疱疹病毒和马疱疹病毒与猫疱疹病毒的慢性感染。
Infect Immun. 1970 Apr;1(4):351-5. doi: 10.1128/iai.1.4.351-355.1970.
2
Activation of latent herpes simplex by trigeminal sensory-root section.通过三叉神经感觉根切断术激活潜伏的单纯疱疹病毒。
N Engl J Med. 1952 Jan 31;246(5):172-6. doi: 10.1056/NEJM195201312460503.
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Activation of latent herpes simplex encephalitis by chemical means.通过化学方法激活潜伏性单纯疱疹性脑炎。
J Infect Dis. 1960 Mar-Apr;106:154-8. doi: 10.1093/infdis/106.2.154.
4
Equine herpes viruses.马疱疹病毒
Virology. 1963 Mar;19:412-6. doi: 10.1016/0042-6822(63)90083-7.
5
Comparison of four horse herpesviruses.四种马疱疹病毒的比较。
J Virol. 1969 Nov;4(5):738-41. doi: 10.1128/JVI.4.5.738-741.1969.
6
Characterization of a cytomegalo-like virus isolated from spontaneously degenerated equine kidney cell culture.从自发退化的马肾细胞培养物中分离出的一种巨细胞样病毒的特性研究。
Proc Soc Exp Biol Med. 1969 Jan;130(1):80-4. doi: 10.3181/00379727-130-33492.