兔和小鼠中枢神经系统中的潜伏性单纯疱疹病毒。
Latent herpes simplex virus in the central nervous system of rabbits and mice.
作者信息
Knotts F B, Cook M L, Stevens J G
出版信息
J Exp Med. 1973 Sep 1;138(3):740-4. doi: 10.1084/jem.138.3.740.
Abstract
Herpes simplex virus (HSV) type 1 induces a long-standing latent infection in the central nervous system of mice and rabbits. The infection was extablished in the brain stems of rabbits after corneal inoculation of the virus, and in the spinal cords of mice after rear footpad infection. In these animals, infectious virus could not be recovered by direct isolation from tissues; it was detected only after the tissues were maintained as organ cultures in vitro.
摘要
单纯疱疹病毒1型可在小鼠和兔子的中枢神经系统中引发长期潜伏感染。在给兔子角膜接种该病毒后，感染在兔子的脑干中建立；在给小鼠后足垫感染后，感染在小鼠的脊髓中建立。在这些动物中，无法通过直接从组织中分离来回收传染性病毒；只有在将组织作为器官培养物进行体外培养后才能检测到。
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