Department of Microbiology, Stritch School of Medicine, Maywood, Illinois 60153.
Infect Immun. 1970 Apr;1(4):351-5. doi: 10.1128/iai.1.4.351-355.1970.
Rabbit eyes experimentally infected with either type 1 or type 2 herpes simplex viruses occasionally released virus spontaneously. Injection of adrenalin was not highly effective for stimulating virus release but did seem to have a slight and erratic activating capacity. No spontaneous virus release were detected from the eyes of six cats infected with cat herpesvirus, but, when adrenalin was administered, an episode of virus release did ensue in one animal. Rabbit spinal cords could be chronically infected with either herpes simplex virus type 2 or equine herpesvirus type 2. The viruses could be reisolated over subsequent months from about half the animals without prior stimulation; the interval between inoculation of trypsinized spinal tissue into tissue cultures and the development of cytopathic effect was often long-more than 4 weeks in some cases.
实验感染 1 型或 2 型单纯疱疹病毒的兔眼偶尔会自发释放病毒。肾上腺素注射对刺激病毒释放的效果并不高，但似乎有轻微且不稳定的激活能力。从感染猫疱疹病毒的 6 只猫的眼中未检测到自发病毒释放，但给予肾上腺素后，其中一只动物确实出现了病毒释放。兔脊髓可慢性感染单纯疱疹病毒 2 型或马疱疹病毒 2 型。无需事先刺激，大约一半的动物在随后的几个月中可以重新分离出病毒；将胰蛋白酶化的脊髓组织接种到组织培养物中与出现细胞病变效应之间的时间间隔通常很长——在某些情况下超过 4 周。
