Kern E R, Hamilton J R, Overall J C, Glasgow L A
Antimicrob Agents Chemother. 1976 Oct;10(4):691-6. doi: 10.1128/AAC.10.4.691.
Oral administration of BL-3849A to adult mice resulted in peak serum interferon titers of 4,000 units from 15 to 30 h after administration, with detectable levels persisting until 48 h. After intraperitoneal (i.p.) inoculation, peak serum interferon titers of 1,000 to 3,000 units were noted between 9 and 18 h. Multiple injections of the inducer by either route resulted in a marked decrease in the interferon response with each successive dose. In mice infected intranasally with the Rochester mouse virus strain of encephalomyocarditis virus, oral treatment with BL-3849A reduced mortality when initiated either 18 h before or 1 h after infection. In contrast, administration of drug by the i.p. route decreased mortality only if begun before infection. In mice inoculated i.p. with encephalomyocarditis virus, treatment by both the oral and the i.p. route decreased the mortality whether initiated 18 h before or 1 h after infection. Treatment by the oral, but not the i.p., route reduced mortality of mice inoculated i.p. with Semliki forest virus or Herpesvirus hominis type 2. BL-3849A appeared to be as effective as tilorone hydrochloride, but less effective than polyriboinosinic-polyribocytidylic acid, in the treatment of these viral infections of mice.
给成年小鼠口服BL - 3849A后，给药后15至30小时血清干扰素滴度峰值达4000单位，可检测水平持续至48小时。腹腔注射后，9至18小时血清干扰素滴度峰值为1000至3000单位。通过任一途径多次注射诱导剂，每次后续剂量的干扰素反应均显著降低。在用罗切斯特株脑心肌炎病毒经鼻感染小鼠时，在感染前18小时或感染后1小时开始用BL - 3849A口服治疗可降低死亡率。相比之下，只有在感染前开始腹腔注射给药才能降低死亡率。在用脑心肌炎病毒腹腔接种的小鼠中，口服和腹腔注射途径治疗在感染前18小时或感染后1小时开始均可降低死亡率。口服途径（而非腹腔注射途径）可降低用塞姆利基森林病毒或人疱疹病毒2型腹腔接种小鼠的死亡率。在治疗小鼠的这些病毒感染方面，BL - 3849A似乎与盐酸替洛隆效果相当，但比聚肌苷酸 - 聚胞苷酸效果差。
