鼠白血病：对干扰素诱导的反应性降低与血清低反应性因子相关。
Murine leukemia: depressed response to interferon induction correlated with a serum hyporeactive factor.
作者信息
Stringfellow D A
出版信息
Infect Immun. 1976 Feb;13(2):392-8. doi: 10.1128/iai.13.2.392-398.1976.
Abstract
Mice injected by the intraperitoneal route with either L1210 or P388 leukemic cells progressively developed a state of hyporeactivity to interferon induction that was dependent upon inducer and time of administration. A circulating factor was detected in the serum of both L1210 and P388 leukemic mice that could transfer hyporeactivity to normal murine cells in vitro. A direct relationship existed between the concentration of serum factor and development of hyporeactivity to interferon induction in vivo. Characterization of the serum hyporeactive factor from P388 or L1210 leukemic mice indicated that both were similar to a hyporeactive factor previously detected in serum from virus-infected mice. These results suggest a cause-effect relationship between the serum hyporeactive factor and development of hyporeactivity in vivo.
摘要
通过腹腔注射途径注入L1210或P388白血病细胞的小鼠逐渐出现对干扰素诱导的低反应性状态，这种状态取决于诱导剂和给药时间。在L1210和P388白血病小鼠的血清中均检测到一种循环因子，该因子可在体外将低反应性转移至正常鼠细胞。血清因子浓度与体内对干扰素诱导的低反应性发展之间存在直接关系。对来自P388或L1210白血病小鼠的血清低反应性因子的表征表明，两者均类似于先前在病毒感染小鼠血清中检测到的低反应性因子。这些结果表明血清低反应性因子与体内低反应性发展之间存在因果关系。
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