前列腺素E1对甲状旁腺激素某些肾脏作用的影响。
Effect of prostaglandin E 1 on certain renal actions of parathyroid hormone.
作者信息
Beck N P, DeRubertis F R, Michelis M F, Fusco R D, Field J B, Davis B B
出版信息
J Clin Invest. 1972 Sep;51(9):2352-8. doi: 10.1172/JCI107047.
Abstract
Parathyroid hormone increased basal adenyl cyclase activity and that increase was inhibited by prostaglandin E(1) (PGE(1)). Tissue cyclic 3',5'-adenosine monophosphate (cyclic AMP) concentrations were increased by parathyroid hormone and that increase was likewise inhibited by PGE(1). Both parathyroid hormone and dibutyryl cyclic AMP increased (32)P incorporation into renal cortical phospholipids. PGE(1) diminished the effect of parathyroid hormone but not dibutyryl cyclic AMP to influence that parameter. PGE(1) likewise modulated the effect of parathyroid hormone but not dibutyryl cyclic AMP to decrease fractional phosphate reabsorption by the renal tubule. It is suggested that PGE(1) inhibits the effect of parathyroid hormone by decreasing its effect on adenyl cyclase. Such interaction may be important in modulating the intracellular action of parathyroid hormone on kidney cortex.
摘要
甲状旁腺激素增加了基础腺苷酸环化酶活性，且该增加被前列腺素E(1)（PGE(1)）所抑制。甲状旁腺激素使组织中环3',5'-腺苷单磷酸（环磷酸腺苷）浓度升高，该升高同样被PGE(1)抑制。甲状旁腺激素和二丁酰环磷酸腺苷均使(32)P掺入肾皮质磷脂中增加。PGE(1)减弱了甲状旁腺激素对该参数的影响，但未减弱二丁酰环磷酸腺苷的影响。PGE(1)同样调节了甲状旁腺激素对肾小管磷酸盐重吸收分数降低的作用，但未调节二丁酰环磷酸腺苷的作用。提示PGE(1)通过降低甲状旁腺激素对腺苷酸环化酶的作用来抑制其效应。这种相互作用在调节甲状旁腺激素对肾皮质的细胞内作用中可能很重要。
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1
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J Histochem Cytochem. 1965 Feb;13:113-6. doi: 10.1177/13.2.113.
2
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Nature. 1965 Jan 23;205:397-8. doi: 10.1038/205397a0.
3
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