儿童急性淋巴细胞白血病一例中的末端脱氧核苷酸转移酶
Terminal deoxynucleotidyl transferase in a case of childhood acute lymphoblastic leukemia.
作者信息
McCaffrey R, Smoler D F, Baltimore D
出版信息
Proc Natl Acad Sci U S A. 1973 Feb;70(2):521-5. doi: 10.1073/pnas.70.2.521.
Abstract
Cells from a patient with childhood acute lymphoblastic leukemia contain an apparent DNA polymerase activity that was not found in any other cells except thymus cells. The enzyme has the properties of terminal transferase, an enzyme known to be found in thymocytes. The cells also contain the three major DNA polymerases found in growing cells. The results suggest that these tumor cells arose from a block in the differentiation of thymocytes. Terminal transferase may be a marker for the origin of leukemic cells.
摘要
一名儿童急性淋巴细胞白血病患者的细胞含有一种明显的DNA聚合酶活性，除胸腺细胞外，在其他任何细胞中均未发现这种活性。该酶具有末端转移酶的特性，末端转移酶是一种已知存在于胸腺细胞中的酶。这些细胞还含有生长细胞中发现的三种主要DNA聚合酶。结果表明，这些肿瘤细胞源于胸腺细胞分化受阻。末端转移酶可能是白血病细胞起源的一个标志物。
相似文献
1
Terminal deoxynucleotidyl transferase in a case of childhood acute lymphoblastic leukemia.儿童急性淋巴细胞白血病一例中的末端脱氧核苷酸转移酶
Proc Natl Acad Sci U S A. 1973 Feb;70(2):521-5. doi: 10.1073/pnas.70.2.521.
2
Mutagenic DNA polymerase in human leukemic cells.人类白血病细胞中的诱变DNA聚合酶。
Proc Natl Acad Sci U S A. 1973 Jan;70(1):245-9. doi: 10.1073/pnas.70.1.245.
3
Terminal deoxynucleotidyl transferase activity in a cell line (molt-4) derived from the peripheral blood of a patient with acute lymphoblastic leukemia.源自一名急性淋巴细胞白血病患者外周血的细胞系（Molt-4）中的末端脱氧核苷酸转移酶活性。
Biochem Biophys Res Commun. 1973 Apr 2;51(3):529-35. doi: 10.1016/0006-291x(73)91346-6.
4
Reverse transcriptase activity of human acute leukaemic cells: purification of the enzyme, response to AMV 70S RNA, and characterization of the DNA product.人急性白血病细胞的逆转录酶活性：酶的纯化、对禽成髓细胞瘤病毒70S RNA的反应以及DNA产物的特性分析
Nat New Biol. 1972 Nov 15;240(98):67-72. doi: 10.1038/newbio240067a0.
5
Terminal deoxynucleotidyl transferase activity in human leukemic cells and in normal human thymocytes.人白血病细胞和正常人胸腺细胞中的末端脱氧核苷酸转移酶活性。
N Engl J Med. 1975 Apr 10;292(15):775-80. doi: 10.1056/NEJM197504102921504.
6
DNA polymerases in lymphoid cells.淋巴细胞中的DNA聚合酶。
Hamatol Bluttransfus. 1974;14:247-55.
7
Selective inhibition of terminal deoxynucleotidyl transferase (TdT) by adenosine ribonucleoside triphosphate (ATP) and its application in the detection of TdT in human leukemia.三磷酸腺苷（ATP）对末端脱氧核苷酸转移酶（TdT）的选择性抑制作用及其在人白血病TdT检测中的应用
Biochem Biophys Res Commun. 1977 Jun 20;76(4):1056-61. doi: 10.1016/0006-291x(77)90963-9.
8
Primer requirement and template specificity of the DNA polymerase of RNA tumor viruses.RNA肿瘤病毒DNA聚合酶的引物需求和模板特异性
Proc Natl Acad Sci U S A. 1971 Jul;68(7):1507-11. doi: 10.1073/pnas.68.7.1507.
9
The synthesis and enzymatic polymerization of nucleotides containing mercury: potential tools for nucleic acid sequencing and structural analysis.含汞核苷酸的合成与酶促聚合：核酸测序和结构分析的潜在工具。
Proc Natl Acad Sci U S A. 1973 Aug;70(8):2238-42. doi: 10.1073/pnas.70.8.2238.
10
Terminal deoxynucleotidyl transferase.末端脱氧核苷酸转移酶
Haematologica. 1978 Jun;63(3):231-40.
引用本文的文献
1
Cutaneous T-Cell Acute Lymphoblastic Leukemia and the Expression Pattern of Terminal Deoxynucleotidyl Transferase Immunostaining in Mycosis Fungoides and Spongiotic Dermatitis.皮肤T细胞急性淋巴细胞白血病以及末端脱氧核苷酸转移酶免疫染色在蕈样肉芽肿和海绵状皮炎中的表达模式
Dermatopathology (Basel). 2019 Sep 4;6(3):182-188. doi: 10.1159/000501581. eCollection 2019 Jul-Sep.
2
Retroviral properties inherent to viral erythrocytic infection in sea bass.海鲈病毒红细胞感染所固有的逆转录病毒特性。
Arch Virol. 1995;140(4):721-35. doi: 10.1007/BF01309960.
3
Terminal deoxynucleotidyl transferase expression in a Thy-l alloantigen variant lymphoma cell line.末端脱氧核苷酸转移酶在Thy-1同种异体抗原变异淋巴瘤细胞系中的表达。
Immunology. 1980 Dec;41(4):799-806.
4
Terminal deoxynucleotidyl transferase activities and glucocorticoid receptors in leukaemia.白血病中的末端脱氧核苷酸转移酶活性与糖皮质激素受体
Br J Cancer. 1981 Jul;44(1):63-7. doi: 10.1038/bjc.1981.148.
5
Detection of terminal transferase in paraffin sections with the immunoperoxidase technique.用免疫过氧化物酶技术检测石蜡切片中的末端转移酶。
Am J Pathol. 1981 Dec;105(3):241-54.
6
Single-cell immunofluorescence assay for terminal transferase: human leukaemic and non-leukaemic cells.末端转移酶的单细胞免疫荧光测定：人类白血病细胞和非白血病细胞
Br J Cancer. 1980 Feb;41(2):159-67. doi: 10.1038/bjc.1980.26.
7
Malignant lymphomas: cell surface markers and advances in classification.恶性淋巴瘤：细胞表面标志物与分类进展
West J Med. 1981 Oct;135(4):276-84.
8
Terminal deoxynucleotidyl transferase (TdT) and membrane receptors in human leukemia and lymphoma -- first experience with lyophilized cells.人白血病和淋巴瘤中的末端脱氧核苷酸转移酶（TdT）和膜受体——冻干细胞的首次经验
Klin Wochenschr. 1981 Apr 15;59(8):365-75. doi: 10.1007/BF01698514.
9
Terminal deoxynucleotidyl transferase in human lymphomas: possible existence of forms with high and low molecular weights.人淋巴瘤中的末端脱氧核苷酸转移酶：可能存在高分子量和低分子量形式
Br J Cancer. 1981 Mar;43(3):312-9. doi: 10.1038/bjc.1981.49.
10
A micromethod for determination of terminal deoxynucleotidyl transferase (TdT) in the diagnostic evaluation of acute leukemias.一种用于急性白血病诊断评估中末端脱氧核苷酸转移酶（TdT）测定的微量方法。
J Cancer Res Clin Oncol. 1980;98(1):91-104. doi: 10.1007/BF00413181.
本文引用的文献
1
2
STUDIES ON THE SYNTHESIS OF DEOXYRIBONUCLEIC ACID BY MAMMALIAN ENZYMES. I. INCORPORATION OF DEOXYRIBONUCLEOSIDE 5'-TRIPHOSPHATES INTO DEOXYRIBONUCLEIC ACID BY A PARTIALLY PURIFIED ENZYME FROM REGENERATING RAT LIVER.哺乳动物酶催化合成脱氧核糖核酸的研究。I. 用来自再生大鼠肝脏的部分纯化酶将脱氧核糖核苷5'-三磷酸掺入脱氧核糖核酸中。
J Biol Chem. 1964 Oct;239:3431-5.
3
DEOXYRIBONUCLEIC ACID POLYMERASE IN L CELLS. I. PROPERTIES OF THE ENZYME AND ITS ACTIVITY IN SYNCHRONIZED CELL CULTURES.L细胞中的脱氧核糖核酸聚合酶。I. 该酶的特性及其在同步化细胞培养中的活性
Biochim Biophys Acta. 1964 Feb 17;80:193-203.
4
Chick embryo poly (rA:dT)-dependent DNA polymerase.鸡胚多聚（rA:dT）依赖的DNA聚合酶。
FEBS Lett. 1971 Oct 15;18(1):130-134. doi: 10.1016/0014-5793(71)80427-1.
5
Deoxynucleotide-polymerizing enzymes of calf thymus gland. V. Homogeneous terminal deoxynucleotidyl transferase.小牛胸腺的脱氧核苷酸聚合酶。V. 均一的末端脱氧核苷酸转移酶。
J Biol Chem. 1971 Feb 25;246(4):909-16.
6
RNA-dependent DNA polymerase in human lymphocytes during gene activation by phytohaemagglutinin.在植物血凝素激活基因过程中人类淋巴细胞中的RNA依赖性DNA聚合酶
Nat New Biol. 1971 Jul 14;232(28):58-61. doi: 10.1038/newbio232058a0.
7
DNA polymerases from human cells.来自人类细胞的DNA聚合酶。
Nat New Biol. 1971 Jun 9;231(23):167-70. doi: 10.1038/newbio231167a0.
8
Low molecular weight deoxyribonucleic acid polymerase from rabbit bone marrow.兔骨髓来源的低分子量脱氧核糖核酸聚合酶
Biochemistry. 1972 Mar 28;11(7):1264-72. doi: 10.1021/bi00757a023.
9
Nucleic acid polymerases of the developing chicken embryo: a DNA polymerase preferring a hybrid template.发育中的鸡胚核酸聚合酶：一种偏好杂交模板的DNA聚合酶。
Proc Natl Acad Sci U S A. 1971 Sep;68(9):2207-11. doi: 10.1073/pnas.68.9.2207.
10
A new method for the large scale purification of Escherichia coli deoxyribonucleic acid-dependent ribonucleic acid polymerase.一种大规模纯化大肠杆菌脱氧核糖核酸依赖性核糖核酸聚合酶的新方法。
J Biol Chem. 1969 Nov 25;244(22):6160-7.
Zotero 插件