多形性胶质母细胞瘤：一项评估特异性主动免疫疗法在接受根治性手术和放疗患者中的价值的对照试验。
Glioblastoma multiforme: a controlled trial to assess the value of specific active immunotherapy in patients treated by radical surgery and radiotherapy.
作者信息
Bloom H J, Peckham M J, Richardson A E, Alexander P A, Payne P M
出版信息
Br J Cancer. 1973 Mar;27(3):253-67. doi: 10.1038/bjc.1973.30.
Abstract
The results are reported of a randomized prospective clinical trial carried out to assess the value of specific active immunotherapy using irradiated autologous tumour cells in patients with glioblastoma multiforme treated by radical surgery and post-operative irradiation. The results in 62 patients show no statistically significant difference in survival between the group receiving adjuvant autologous tumour cells and those treated with surgery and radiotherapy alone. All 27 patients receiving tumour cells were dead at 30 months, whereas 7 of the 35 controls were alive at this time. The results were considered sufficiently discouraging to abandon the trial at this stage on the grounds that there was sufficient evidence in this study that the administration of irradiated autologous cells was of no benefit to patients with high grade astrocytomata.
摘要
报告了一项随机前瞻性临床试验的结果，该试验旨在评估在接受根治性手术和术后放疗的多形性胶质母细胞瘤患者中，使用经辐照的自体肿瘤细胞进行特异性主动免疫治疗的价值。62例患者的结果显示，接受辅助自体肿瘤细胞治疗的组与仅接受手术和放疗的组在生存率上无统计学显著差异。所有27例接受肿瘤细胞治疗的患者在30个月时均死亡，而35例对照组患者中有7例此时仍存活。这些结果被认为令人沮丧，足以在现阶段放弃该试验，因为本研究中有充分证据表明，给予经辐照的自体细胞对高级别星形细胞瘤患者无益处。
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