Brenchley J E, Ingraham J L
J Bacteriol. 1973 May;114(2):528-36. doi: 10.1128/jb.114.2.528-536.1973.
A cold-sensitive mutant of Salmonella typhimurium LT2 that grows at 37 C but not at 20 C has altered repression regulation in at least two amino acid biosynthetic pathways (histidine and isoleucine). The lesion conferring cold sensitivity that is linked with hisW is recessive. Assays for the acceptance of some amino acids by transfer ribonucleic acid (tRNA) reveal a decreased ability of the mutant tRNA to accept arginine, phenylalanine, and histidine. A mutation in a gene for tRNA maturation is a likely possibility for the mutation producing these effects on growth, regulation, and amino acid acceptance.
鼠伤寒沙门氏菌LT2的一个冷敏感突变体，能在37℃生长但不能在20℃生长，其在至少两条氨基酸生物合成途径（组氨酸和异亮氨酸）中改变了阻遏调节。与hisW连锁的导致冷敏感的损伤是隐性的。对转运核糖核酸（tRNA）接受某些氨基酸的检测表明，突变体tRNA接受精氨酸、苯丙氨酸和组氨酸的能力下降。tRNA成熟基因中的突变很可能是产生这些对生长、调节和氨基酸接受影响的突变原因。
