环戊甘氨酸对鼠伤寒沙门氏菌代谢的影响。
Effect of cyclopentaneglycine on metabolism in Salmonella typhimurium.
作者信息
O'Neill J P, Freundlich M
出版信息
J Bacteriol. 1972 Aug;111(2):510-5. doi: 10.1128/jb.111.2.510-515.1972.
Abstract
Cyclopentaneglycine (CPG) inhibited the growth of wild-type Salmonella typhimurium. The inhibition was overcome by isoleucine or any isoleucine precursor formed after threonine. CPG appeared to mimic isoleucine as a strong inhibitor of the activity of l-threonine deaminase. The analogue was a poor inhibitor of isoleucyl-transfer ribonucleic acid synthetase. CPG did not appear to be incorporated into protein nor did it replace isoleucine in repression. Cells that had recovered from growth inhibition by CPG had derepressed levels of the isoleucine-valine biosynthetic enzymes.
摘要
环戊基甘氨酸（CPG）抑制野生型鼠伤寒沙门氏菌的生长。异亮氨酸或苏氨酸之后形成的任何异亮氨酸前体均可克服这种抑制作用。CPG似乎作为L-苏氨酸脱氨酶活性的强抑制剂模拟异亮氨酸。该类似物是异亮氨酰转移核糖核酸合成酶的弱抑制剂。CPG似乎未掺入蛋白质中，在阻遏作用中也不能取代异亮氨酸。从CPG引起的生长抑制中恢复的细胞，其异亮氨酸-缬氨酸生物合成酶的水平已去阻遏。
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