环磷酸腺苷的多效性调控：与环磷酸鸟苷的相互作用及微管的可能作用
Pleiotypic control by cyclic AMP: interaction with cyclic GMP and possible role of microtubules.
作者信息
Kram R, Tomkins G M
出版信息
Proc Natl Acad Sci U S A. 1973 Jun;70(6):1659-63. doi: 10.1073/pnas.70.6.1659.
Abstract
Previous studies have shown that exogenous dibutyryl cyclic AMP inhibits the uptake of uridine, leucine, and 2-deoxyglucose by cultured mouse fibroblasts. 3':5'-cyclic GMP is shown here to counteract these inhibitory effects as well as the inhibition of precursor transport and leucine incorporation into proteins produced by prostaglandin E(1). We conclude, therefore, that cyclic GMP antagonizes the "pleiotypic" effects of cyclic AMP in these cells. Colcemid and vinblastine, but not cytochalasin B, reverse the transport inhibition caused by cyclic AMP without affecting the intracellular concentrations of cyclic AMP. These results suggest the possibility that cyclic AMP regulates the membrane transport of certain substrates by influencing the organization of microtubules.
摘要
以往的研究表明，外源性二丁酰环磷腺苷抑制培养的小鼠成纤维细胞对尿苷、亮氨酸和2-脱氧葡萄糖的摄取。本文显示3':5'-环鸟苷酸可抵消这些抑制作用，以及前列腺素E(1)对前体转运和亮氨酸掺入蛋白质的抑制作用。因此，我们得出结论，环鸟苷酸在这些细胞中拮抗环磷腺苷的“多效性”作用。秋水仙酰胺和长春花碱而非细胞松弛素B可逆转环磷腺苷引起的转运抑制，而不影响细胞内环磷腺苷的浓度。这些结果提示环磷腺苷可能通过影响微管的组织来调节某些底物的膜转运。
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