Haire M, Fraser K B, Millar J H
Br Med J. 1973 Sep 22;3(5881):612-5. doi: 10.1136/bmj.3.5881.612.
Immunoglobulins M and G specific for meales, herpes simplex, and rubella viruses were assayed by the fluorescent antibody method in sera and cerebrospinal fluids (C.S.F.) obtained simultaneously from 30 patients with multiple sclerosis, 30 patients with other neurological diseases, and 30 "normal" control subjects. Sera of 11 out of 30 patients with multiple sclerosis had IgM which reacted specifically with measles virus-infected cells, compared with 2 out of 30 of the patients with other neurological diseases and none of the 30 normal controls. Virus-specific IgM was not found in C.S.F. by this method.The geometric mean titre of measles virus-specific IgG in serum was significantly higher in the multiple sclerosis group than in either control group, and while IgG specific for all three viruses was found in C.S.F., suggesting transfer across the blood-brain barrier, measles IgG predominated.
采用荧光抗体法，对同时采集的30例多发性硬化症患者、30例其他神经系统疾病患者和30名“正常”对照者的血清及脑脊液（CSF）进行检测，以测定针对麻疹、单纯疱疹和风疹病毒的免疫球蛋白M和G。30例多发性硬化症患者中有11例血清中的IgM能与感染麻疹病毒的细胞发生特异性反应，相比之下，30例其他神经系统疾病患者中有2例，30名正常对照者中无一例出现这种情况。通过该方法在脑脊液中未发现病毒特异性IgM。多发性硬化症组血清中麻疹病毒特异性IgG的几何平均滴度显著高于任一对照组，虽然在脑脊液中发现了针对所有三种病毒的IgG，提示有物质穿过血脑屏障，但麻疹IgG占主导。
